| # PP489 Optimization Variants Iter0 x TIGIT (YM_693) | |
| ## Overview | |
| YM_693 is a dataset of anti-TIGIT designs against TIGIT. This dataset contains only 2 targets, but they are species homologs of human and mouse. The designs offer a few mutations to study the local interaction between and TIGIT. This is a dataset to explore relative affinities to the parent for antibody optimization. | |
| ## Experimental details | |
| We studied the efficacy of generating binders with different model hyperparameters. This dataset includes 26726 unique scFvs and 2 unique target sequences. | |
| A more extensive methods section can be found in our publication [here](https://pmc.ncbi.nlm.nih.gov/articles/PMC12296056/). | |
| ## Misc dataset details | |
| We define the following binders: | |
| ### A-library (scFvs) | |
| There are several terms you can filter by: | |
| - `wt_<i>`: These are WT replicates. | |
| - `candidate_`: Various mutations of PP489 | |
| ### Alpha-library | |
| - `TIGIT_22-137_POI-AGA2`: Human TIGIT | |
| - `TIGIT_Mouse`: Mouse TIGIT | |