# PP489 Optimization Variants Iter0 x TIGIT (YM_693)

## Overview

YM_693 is a dataset of anti-TIGIT designs against TIGIT. This dataset contains only 2 targets, but they are species homologs of human and mouse. The designs offer a few mutations to study the local interaction between  and TIGIT. This is a dataset to explore relative affinities to the parent for antibody optimization.

## Experimental details

We studied the efficacy of generating binders with different model hyperparameters. This dataset includes 26726 unique scFvs and 2 unique target sequences.

A more extensive methods section can be found in our publication [here](https://pmc.ncbi.nlm.nih.gov/articles/PMC12296056/).

## Misc dataset details

We define the following binders:

### A-library (scFvs)

There are several terms you can filter by:

- `wt_<i>`: These are WT replicates.
- `candidate_`: Various mutations of PP489

### Alpha-library

- `TIGIT_22-137_POI-AGA2`: Human TIGIT
- `TIGIT_Mouse`: Mouse TIGIT