Add iter0 iter1 definition, fix typos

README.md

@@ -27,7 +27,7 @@ configs:
 ---
 # A-Alpha Datasets
 
-Protein-protein interactions (PPIs) are fundamental to countless biological processes. One of the most informative biophysical properties of a PPI is the binding affinity: the strength of how two proteins interact. Yet, despite its importance, publicly available affinity data remains limited, constaining the development and benchmarking of protein modeling methods.
+Protein-protein interactions (PPIs) are fundamental to countless biological processes. One of the most informative biophysical properties of a PPI is the binding affinity: the strength of how two proteins interact. Yet, despite its importance, publicly available affinity data remains limited, constraining the development and benchmarking of protein modeling methods.
 
 Our high-throughput yeast mating assay, [AlphaSeq](https://www.pnas.org/doi/10.1073/pnas.1705867114), enables the quantitative measurement of PPIs at scale (often generating libraries up to 1M interactions per experiment!).
 
@@ -137,6 +137,10 @@ Affinity measurements are reported in log10 Kd nM (a value of 0 indicates 1 nM,
 
 Not all PPIs form detectable interactions; weak or non-binding interactions may result in no paired barcode reads, yielding NaN values. For these cases, it may be more useful to look at the lower or upper bound affinities to help interpret the range of possible affinity within the assay.
 
+### What do Iter0 / Iter1 mean?
+
+Iter0 and Iter1 (abbreviated for Iteration) are our nomenclature for describing antibody variant libraries designed for antibody optimization campaigns. Iter0 libraries are generated in a zero-shot fashion (ie random mutations or selections by ESM) while Iter1 libraries are generated with models trained on Iter0 datasets.
+
 ### How should I cite this dataset?
 
 Please cite:

data/YM_0693/README.md

@@ -19,7 +19,7 @@ We define the following binders:
 There are several terms you can filter by:
 
 - `wt_<i>`: These are WT replicates.
-- `candidate_`: Various mutations of Pembrolizumab
+- `candidate_`: Various mutations of PP489
 
 ### Alpha-library