Can people with Cystic Fibrose reproduce? Will their children inherit this disease?
552790
"At least 97% of men with CF are sterile due to congenital bilateral aplasia of the vas deferens (CBAVD), an absence of the vas deferens. There are new technologies that are offering hope to men with CF who desire to father a child since sperm is present. This would involve aspiration and In vitro fertilization. Having a discussion with a fertility specialist would be helpful in those cases. Additionally, men who do not have cystic fibrosis but are born with congenital absence of the vas deferens have an increased risk being carriers of the CF gene.\n\nWomen with CF may also have impaired fertility, as thicker cervical mucus may prevent sperm from entering the uterus and thus reduce the likelihood of unassisted conception"
825223
I don't understand your use of the word controlled.\nIf you mean what is the relationship of recessive genes to Cystic Fibrosis?\nBecause the trait for CF is attached to a recessive gene it means that when that gene is passed on to a child it is harmless on its own.  The disease only occurs when one woman with the recessive linked gene mates with a male with the same recessive gene. Two recessives result in the disease happening in the child.\nThe two parents who only have half the material each on their genes are ''carriers'' of the disease.\nMost cystic fibrosis children are blond and blue eyed because these too are thought to be part of recessive genes.  \nIs that what you want to know?
293799
Yes- they do.  Women with DS are fertile. Men with DS have traditionally been considered sterile; however, there have been two documented cases of adult men with DS fathering children.
44211
Girls with CF should be able to get pregnant.  Men with CF are sterile though.
14618
It depends on the cause of the defect.  Your children might get it only if it's caused by a genetic defect.  If it's caused by a development problem in the womb, then probably not.
508393
Haha, if the male is infertile, how to you expect him to have kids to pass his infertility to!!!!
195654
I think it depends on what kind of mental handicap the parents have. Unless they are mature enough and can handle the responsibilities of being a parent then no - they shouldn't be able to raise children. But that should go for any parents...
119148
A recessive trait can be passed on in a family lineage infinitely and not present itself until two people who have that recessive gene mate and produce a child who gets both the recessive gene from both parents.
456105
In some states and they can reproduce fairly risk free but its still a risk and all cousins reproducing does is bring out reccessive genes so for all you know it could be a genius gene versus a bad gene its been known to happen
637142
no doesnt matter as far as blood groups go. AB, B, O whatever theyre all just as good. \n\nhowever, genetic testing to see if people carry a rececive gene that could result in diseases like cystic fibrosis or tay-sachs might be a good idea.... but you could always adopt or hope your kids dont get those diseases, so i wouldnt look to far into it. plus you might scare off your girl if you make her get all kinds of blood tests before you get married
800997
It doesn't and shouldn't.\n\nYes, we are gay/lesbian, yes it's true that two gay males or two lesbians cannot have children together without outside "aid." This is a known fact.\nIt is also a known fact that an infertile female or male cannot have children with either males OR females, therefore the argument is moot.\n\nI am a lesbian, I have a son, a biological child whom my partner and I have raised together for the past ten years. He does have a father, whom he has a relationship with, albeit strained, but he does know his father. My partner is to my son, another parental figure whom he respects moreso than even his legal step-mother who is married to his father. \n\nHe has never had to "explain" to anyone about his parents (my partner and myself). His friends simply aren't that shallow. They know he has good parents and he is well cared for. It doesn't matter to him or his friends that we are a lesbian couple. He has never been picked on, bullied or lost friends because of who his parents are. He is not depressed or a loner, he's out going and is well liked. \n\nThere have been studies done by respected, peer reviewed organizations/associations who have found that children raised by same sex couples are no more likely to be gay themselves, are usually better adjusted and more tolerant than children raised by opposite sex parents. \n\nChildren raised by same sex parents are children who are WANTED. Same sex couples have to put more attention and more dillegence into either attaining a child, becoming pregnant or retaining custody of their natural children...same sex couples actually WANT these kids, they are more willing to do anything to provide stable, loving homes for their children. \nSame sex couples go out of their way to teach their children tolerance, acceptence, honesty and love...unconditional love.
372507
It is the most common genetic disease among people with European ancestry. Approximately one in every 25 people of European descent is a carrier of one of the cystic fibrosis mutations, having one normal gene and one CF gene.Whereas, the carrier rate is 1 in 17,000 live births of African Americans, and 1 in 90,000 live births of the Asian population of Hawaii.[2]\n\nSince cystic fibrosis is recessive, both copies of the gene have to be CF genes to cause the symptoms that occur in about 1 in every 2500 children. The high incidence of this lethal gene can be explained by the fact that CF carriers, who don't show any symptoms, enjoy some protection against cholera, since the extreme water loss in the intestines is prevented. More recently, evidence suggests CF genes could give protection against typhoid fever. People from areas where cholera and typhoid fever are not problems show a much lower incidence of CF. Genetic counseling and genetic testing is recommended for families who may be carriers of cystic fibrosis.\n\nAs CF is caused by a pair of recessive gene mutations, couples with the same CF mutation will have a one in four chance that their offspring is afflicted with CF. Prenatal and preconceptional screening will identify parents at risk to have offspring with CF. Different population groups have a different prevalence of CF, thus such screening tests will be most useful in populations with a high prevalence. According to ACOG, the risk of being a carrier for an abnormal gene sequence related to CF is 1/24 for Ashkenazi Jews, 1/25 for non-Hispanic Caucasians, 1/46 for Hispanic Americans, 1/ 65 for African Americans, and 1/94 for Asian Americans. Typically one partner is screened, and if found positive the other partner undergoes the test, but in situations of time constraints, i.e. during prenatal testing, both partners may undergo testing. Genetic testing examines a panel of the most common forms of gene mutations that can lead to CF, typically 23 mutations are checked. However as over 1,300 mutations are linked to CF, there remains a residual risk even in the presence of negative testing. Couples who undergo preconceptional testing can choose among several reproductive options, including PGD prior to establishing a pregnancy, prenatal fetal testing by chorionic villus sampling or amniocentesis, or the use of alternative gametes (third party reproduction).\n\nCystic fibrosis was first described as a disease in the late 1930s by Dorothy Hansine Andersen.In 1988, the first mutation for CF, ΔF508, was discovered by Francis Collins, Lap-Chee Tsui and John R. Riordan on the seventh chromosome of the human genome. Research has subsequently found over 1000 different mutations that may cause CF, however ΔF508 accounts for approximately 70% of CF patients in Europe (this percentage varies regionally). Lap-Chee Tsui led a team of researchers at the Genomic Biology Program of the Research Institute, at The Hospital for Sick Children in Toronto to discover the gene responsible for CF in 1989.
630487
only with artificial insemination or a surragate mother,\ntwo people from the sex cant make children and men cnat have babies anyway, only make em.
788709
Firstly congrats on surviving this nasty cancer.\nAs for having children, you may need to see a fertility specialist, there is some talk that the treatment protocols for leukaemia can make you infertile because they are so strong.\nIf you are able to have children, i dont believe there would be an issue of your child getting leukaemia, it is not ment to be genetic. But I would also see a genetic councillor if you are able to have children. Good luck!
712428
Cystic fibrosis, or 'mucoviscidosis', is a hereditary disease. A defective gene results in an inability to transport salt in certain kinds of cells in the lungs and in the pancreas. It is the most common hereditary disease in Western Europe. \n\nWhy does a person get cystic fibrosis?\n\nCystic fibrosis is an 'autosomal recessive' disease, which means that both parents have a gene defect that they pass on to their offspring. But the child will have cystic fibosis only if it inherits both of the defective copies of the gene. There is a 1:4 chance of this happening. \n\nIn the other three out of four chances the child will inherit a normal copy of the gene and be unaffected by cystic fibrosis. The exact mechanism is not known, but the altered salt transport severely thickens the mucus in the respiratory passages. This makes the respiratory passages more susceptible to bacterial infection, most frequently Staphylococcus and Pseudomonas.\n\nHow can I tell if I have cystic fibrosis?\n\nThe symptoms are usually noticeable in the first year of life. If cystic fibrosis is suspected, the diagnosis can be confirmed through a special sweat test. The GP can then make a referral to a cystic fibrosis centre at a hospital.\n\nIn the lungs, the disease results in repeated cases of pneumonia and breathing difficulties. The pancreas becomes less able to produce digestive juices, which may result in weight loss and greasy diarrhoea.\n\nThe disease increases the salt content in the patient's sweat. At high temperatures this may result in the patient losing too much salt and suffering heatstroke.\n\nWhat can I do?\n\nIf somebody is expecting to be a parent, they should check if there have been any cases of cystic fibrosis in their family. If there is, they can talk to their doctor about being referred to a genetic counsellor. The counsellor will be able to assess the chances of the baby having the disease, at which point a decision can be made about continuing the pregnancy.\n\nSomeone with cystic fibrosis must avoid unnecessarily straining their lungs, for instance by smoking. Lung exercises with a special mask (PEP) are often useful.\n\nFuture prospects\n\nPreviously, the prognosis for cystic fibrosis sufferers was very gloomy. But the treatment is getting better and now there is an 80 per cent chance that a child with cystic fibrosis will live for over 40 years.\n\nGenetic treatment holds considerable promise over the next decade but it will be in the future before this becomes any kind of mainstream treatment.\n\nHow is cystic fibrosis treated?\n\nThe treatment aims to maximise the lung function for as along as possible.\n\n\nCommon treatments include lung physiotherapy as well as antibiotics to minimise the risk of lung infections. Complications within the pancreas can be managed by controlling the patient's diet, and providing supplements of pancreatic enzymes (eg Creon) to add to food.\n\n\nAs a result of cystic fibrosis, some patients may also suffer asthma, which can be alleviated by asthma inhalers.\n\n\nA lung or a lung and heart transplant may be necessary if the lung function deteriorates very significantly.
907371
I know of a family that had 4 kids......they were first cousins, and they ended up having 4 kids with learning disabilities....and downs syndrome......\n\nSo I would say no...do not have kids unless you are prepared to have kids with many challenges.....
1092146
Yes. Fragile X is carried by females but affects male offspring. If you are a woman from a family where males have fragile X make sure you have genetic counselling before going ahead with a family. If fragile x is a possibility often the best way forward is to have a donated egg implant which can be fertilized by your partner. The first port of call should be your GP before you consider having a family. DO NOT BE FOBBED OFF WITH ADVICE LIKE "IT WILL PROBABLY BE OK" as some GP's are not up to speed with this. Ensure you are referred to your local hospital first.