Why do NSAIDS cause problems with the cardiovascular system?
536497
NSAIDs thin the blood, decreasing the inflammatory response. But they can also weaken the arterial and cardiac walls with long-term use.
99134
No, actually, it's good for you. Also, when my neighbor went into the ER with chest pains, they gave her 4 childrens chewable aspirins right away. Aspirin thins your blood, and helps to keep you from having a heart attack. Just use caution, because some people are allergic to aspirin. If you aren't allergic, then it's a good thing. \n\nAlso, when I broke my ankle and was in a cast, my doctor insisted that I take an aspirin every day to keep from getting blood clots where the cast was. Aspirin is good for many things...not just for headaches anymore!
544707
Association however strong, does not imply causation. There is no significant evidence that Reye's syndrome is caused by the use of aspirin. Here is a list that claims that Reye's syndrome could not be associated with aspirin usage:\n1. Reye's syndrome did not exist before 1950- it suddenly appeared in the 1950s but aspirin had been used since 1899; paracetamol (acetaminophen) was discovered in 1955.\n2. Reye himself concluded that aspirin was not a cause of the syndrome.\n3. Aspirin ingestion occurred in patients with viral illnesses who did not develop Reye's syndrome.\n4. Uncertainty about the timing of the onset of the syndrome- whether the data are anaylysed with protracted vomiting or the onset of altered mental status as the starting point is material to whether or not an association with phenothiazines is found. \n5. International differences in patterns of the disease and association with aspirin.\n6. Reye's syndrome was disappearing before label warnings were introduced in 1986.\n7. Some cases of Reye's may have had undiagnosed inborn errors of metabolism.\n\nOther studies have also concluded that "an aspirin a day, keeps the doctor away." With these catchy phrases and hidden side effects that people may not be aware of, people have started taking daily dosages of aspirin to prevent atherosclerosis. This maybe true for the populatoin in general, but not specifically for the elders. 65 and older users of aspirin have shown little or no benefits, on the other hand many side effects arised.\n\nBleeding and hemmoraging are major problems for the elderly population which uses aspirin, therefore being suseptible to adverse effects of the drug is on person to person bases. If no bleeding, allergic reactions, or other side effects arise than aspirin is great for headache and pain relief and may even prevent strokes or heart attacks. Hopefully you found this useful and not baised... I am niether trying to promote the drug or telling you to avoid it... Just informing my fellow "Yahoo Answerer". GL
168396
Doctors don't recommend aspirin because it's good for your health - they recommend it because it thins blood which will help if you have high blood pressure or heart problems.  Except that they are finding now that this doesn't work as well (if at all) for women.\n\nOTOH, constant use over a period of time contributes to ulcers, if not causing them.\n\nNO medicine is without negative side effects, and should only be taken if the benefit outweighs the risk.  It is best that YOU know what the risk is when you take medicine so you can decide if it is worth it to you.
1014106
anti-inflammatory medicine can be very dangerous if not taken under medical supervision and for long periods of time. aspirin for example can attack the stomach and can even cause an ulcer in people with sensitive stomach, even taken in the recommended dosage.\n  my recommendation is to talk with your doctor or pharmacist and see what they say about it
153097
Vitamin E is good but when medication causes this problem there is not a lot you can do. Discuss this side effect with your doctor! Being a nurse i know this is a common problem associated with quite a few medications. Especially those used to treat heart problems and highblood pressure. Some times it just takes patience and time. Good Luck and really be sure you talk to your doctor. He or She may be able to find a alternate medication for you.
888739
Aleve is a trade name for Naprosyn, a non steroidal anti-inflammatory drug (NSAID) similar to ASA or Ibuprofen.  While available over the counter in USA, it is a prescription product in other countries, such as Canada.\n\nAll NSAIDs have potential to cause stomach ulcers, gastritis, and bleeding.  They can also cause kidney failure in excess doses....not liver failure, that is from Acetominiphen (Tylenol)\n\n16 is a very large dose in a day...and may cause any of the above, or just an upset stomach and heartburn symptoms.
1113535
Its comman problem. in my experince most of patients do well with analgesic NSAID and antispasmodic like buscopan.
996809
Because unlike vitamin E (which thins the blood, and prevents stroke and heart attack), which would require you go to a health food store AND NOT A PHARMACY, aspirin kills at least 2,000 people a year, and doctors don't like to recommend things that don't have any chance of killing you....they equate harmlessness with ineffectiveness.  And they are threatened by natural alternatives because it takes all the power away from their drug dealing mentalities, and keeps them from driving a Mercedes, or buying implants for their mistresses.
323697
It probably has to do with the sudden outpouring of stress hormones - catecholamines - that swamp the body. These can affect the peripheral blood vessels, reducing blood supply to the muscles, as well as central blood vessels. Some people have had profound heart dysfunction after hearing bad news or witnessing traumatic incidents; they look as if they've had a massive heart attack, but it's temporary.
542939
Misinformation is the biggest reason.  A previous answer suggests that every time one takes a pain pill it harms the stomach.  That's an example of misinformation that can scare people away from reasonable steps that could make them comfortable.  Aspirin has a reputation for harming the lining of the stomach. That can happen, but only after taking aspirin in large, frequent doses for many days.  The simple solution to that is to take enteric-coated aspirin, which does not dissolve in the stomach.  If one is allergic to aspirin - and one should NEVER assume on one's own that one is allergic - then there are other over-the-counter medicines that can relieve cramps.  Motrin is one, tylenol is another.  Then there are the medicines meant specifically for menstrual cramps, such as Pamprin.  Several of the women I've known very personally have found that a heating pad or hot water bottle held against the area that's hurting can help the painkiller pills work better. It is foolish to fail to make onesself comfortable when it's so easy and inexpensive to do so because Aunt Myrtle or some other poorly informed person tells you it is dangerous.   Take your pills and brew Aunt Myrtle a nice cup of tea and change the subject!
242514
It is possible that ibuprofen may affect blood pressure control because it inhibits the synthesis of prostaglandins (hormone-like agents that influence the functions of the kidney). Reports have been published that ibuprofen may affect blood pressure control in people taking beta-blockers, diuretics, ACE inhibitors and alpha-blockers. Conversely, there are also reports of no problems with some of these drugs when people are also taking ibuprofen. \nIbuprofen should only be taken under medical supervision by someone taking antihypertensive drugs (drugs that lower raised blood pressure). However, the evidence that ibuprofen interacts with antihypertensive drugs is inconclusive.
555178
We are unsure of the exact cause of ocular migraines.  They can occur with or without a headache.  I do not know of any direct correlation between NSAIDs or any other medication use with ocular migraines.
220353
It prevents the clotting of the blood which can be harmful for the heart. Used for fever and a pain reliever with anti inflammatory aspects.
540490
Treatment\nTreatments for arthritis have improved in recent years. Most treatments involve medications. But in some cases, surgical procedures may be necessary.\n\nMedications\nMedications for rheumatoid arthritis can relieve its symptoms and slow or halt its progression. They include:\n\nNonsteroidal anti-inflammatory drugs (NSAIDs). This group of medications, which includes aspirin, helps relieve both pain and inflammation if you take the drugs regularly. NSAIDs that are available over-the-counter include aspirin, ibuprofen (Advil, Motrin, others) and naproxen sodium (Aleve). These are available at higher dosages, and other NSAIDs are available by prescription — such as ketoprofen, naproxen (Anaprox, Naprosyn), tolmetin (Tolectin), diclofenac (Voltaren), nabumetone (Relafen) and indomethacin (Indocin). Taking NSAIDs can lead to side effects such as indigestion and stomach bleeding. Other potential side effects may include damage to the liver and kidneys, ringing in your ears (tinnitus), fluid retention and high blood pressure. NSAIDs, except aspirin, may also increase your risk of cardiovascular events such as heart attack or stroke. \nCOX-2 inhibitors. This class of NSAIDs may be less damaging to your stomach. Like other NSAIDs, COX-2 inhibitors — such as celecoxib (Celebrex) — suppress an enzyme called cyclooxygenase (COX) that's active in joint inflammation. Other types of NSAIDs work against two versions of the COX enzyme that are present in your body: COX-1 and COX-2. However, there's evidence that by suppressing COX-1, NSAIDs may cause stomach and other problems because COX-1 is the enzyme that protects your stomach lining. Unlike other NSAIDs, COX-2 inhibitors suppress only COX-2, the enzyme involved in inflammation. Side effects may include fluid retention and causing or exacerbating high blood pressure. Furthermore, this class of drugs has been linked to an increased risk of heart attack and stroke. \nCorticosteroids. These medications, such as prednisone and methylprednisolone (Medrol), reduce inflammation and pain, and slow joint damage. In the short term, corticosteroids can make you feel dramatically better. But when used for many months or years, they may become less effective and cause serious side effects. Side effects may include easy bruising, thinning of bones, cataracts, weight gain, a round face and diabetes. Doctors often prescribe a corticosteroid to relieve acute symptoms, with the goal of gradually tapering off the medication. \nDisease-modifying antirheumatic drugs (DMARDs). Physicians prescribe DMARDs to limit the amount of joint damage that occurs in rheumatoid arthritis. Taking these drugs at early stages in the development of rheumatoid arthritis is especially important in the effort to slow the disease and save the joints and other tissues from permanent damage. Because many of these drugs act slowly — it may take weeks to months before you notice any benefit — DMARDs typically are used with an NSAID or a corticosteroid. While the NSAID or corticosteroid handles your immediate symptoms and limits inflammation, the DMARD goes to work on the disease itself. Some commonly used DMARDs include hydroxychloroquine (Plaquenil), the gold compound auranofin (Ridaura), sulfasalazine (Azulfidine), minocycline (Dynacin, Minocin) and methotrexate (Rheumatrex). Other forms of DMARDs include immunosuppressants and tumor necrosis factor (TNF) blockers. \nImmunosuppressants. These medications act to tame your immune system, which is out of control in rheumatoid arthritis. In addition, some of these drugs attack and eliminate cells that are associated with the disease. Some of the commonly used immunosuppressants include leflunomide (Arava), azathioprine (Imuran), cyclosporine (Neoral, Sandimmune) and cyclophosphamide (Cytoxan). These medications can have potentially serious side effects such as increased susceptibility to infection. \nTNF blockers. These are a class of DMARDs known as biologic
1060769
Aspirin to Prevent Blood Clots\nAbout one in four heart attacks and strokes may be prevented by aspirin.\n\nA daily low dose of aspirin lowers the risk of having a heart attack or stroke if you have:\n\n    * angina.\n    * a previous heart attack (myocardial infarction).\n    * peripheral vascular disease.\n    * a previous stroke or transient ischaemic attack (TIA).\n    * certain other heart and blood vessel conditions.\n\nThe usual dose is 75 mg. This is a lot less than the dose for pain relief. If you need to take painkillers (eg for headaches) it is best to take alternative painkillers such as paracetamol
407323
Aspirin and more importantly it's breakdown product, is an irreversible inhibitor of COX enzymes (non-specific, it inhibits COX-1, 2, and 3) which are critical enzymes for platelet aggragation and prostoglandin synthesis. A number of studies have failed to show an inhibition of complement with aspirin-in fact, in some subjects, aspirin actually induced c3 and c5a.  The primary anti-inflammatory effects are also through inhibition of COX enzymes, as well as inhibition of NF-kappaB, the transcription factor most responsible for TNFa production.