how does tranferrin saturation percentage affects erythropoiesis?
452157
http://sickle.bwh.harvard.edu/iron_transport.html\n\nLooks like transferrin is necessary to reutilize iron released from dead RBC.  It's been a year or so since BASIC A&P for me, and it is not my field.  This link would be a good start.
255261
THE ANSWERS TO THE TWO QUESTIONS ARE DIFFERENT AS UNDER:\nANS 1 ) ANAEMIA.\n        ANAEMIA IS DEFINED AS THE DECREASE IN HEMOGLOBIN LEVEL THAN NORMAL FOR THAT INDIVIDUAL IN CONSIDERATION TO HIS SEX, AGE, ALTITUDE OF RESIDENCE.\nTHE NORMAL LEVEL IN MALES IS 14 -16 GM%\n                 IN FEMALES IS 11 - 14 GM %\nANS 2 ) POLYCYTHEMIA \n        POLYCYTHEMIA IS THE DISORDER IN WHICH THERE IS INCREASED RED BLOOD CELL COUNT AS REGARDS TO THE NORMAL RANGE FOR THAT INDIVIDUALS AGE, SEX AND ALTITUDE OF RESIDENCE.\nTHE NORMAL LEVELS IN MALES IS 4.5 - 6\n                  IN FEMALES IS 3.5 - 5 \n N.B. : LEUKEMIA IS A NEOPLASTIC DISORDER IN WHICH THERE IS INCREASED RBC COUNT
588190
Iron is necessary to make hemoglobin, the substance that carries oxygen through your blood to all the cells in your body. Hemoglobin is what makes red blood cells red. With insufficient iron, and therefore not enough hemoglobin, red blood cells become small and pale and don't carry enough oxygen. You may have heard the phrase "tired blood." This really means blood that is low in iron and that can't carry enough oxygen to vital organs and muscles. "Tired blood" results in a tired body. \n\nIron is needed not only for blood, but also for brains. Neurotransmitters, the neurochemicals that carry messages from one nerve to another, require sufficient iron to function properly. A person with an iron deficiency may have a tired mind as well as a tired body.
807903
Erythrocytes are produced in the bone marrow in adults and they are produced in the liver in an embryo. The spleen filters out old RBCs.
564697
Nothing much.\n\nThe first point to realise is that the blood you donate will almost certainly not be transfused as whole blood. It will be separated into platelets, red blood cells, plasma and so forth. Red blood cells (RBCs),plasma and platelets have no nuclei and so have none of you DNA worth speaking of.\n\nThe only part of the blood that contains measurable DNA is the white blood cells. They won't get transfused in most cases. But even if whole blood was transfused the WBCs only have a life expectancy of a few weeks. So unless someone committed a crime within weeks of a massive whole blood transfusion it simply isn't an issue. The odds of anyone who receives a massive whole blood transfusion being able to commit a crime is very slim to say the least.\n\nIn the ridiculously improbable scenario that someone does commit a crime AND cuts themselves AFTER a massive whole blood transfusion you are still in the clear. The blood will contain genetic material form you and him and several other donors. That will not produce a positive match for your DNA. At worst it will indicate that you and at least three other people were all there bleeding in the same spot at the same time, which nobody will believe given the blood spatter pattern.\n\nRelax, it's just not an issue.
239929
Hct is the proportion of blood volume that is occupied by red blood cells.  Conditions that raise it may be a chronic state of hypoxia, where the body grows more rbc's, such as high altitude, and lung problems, even sever dehydration.  Lower hct is typically anemia or bloodloss.
1124178
Actually, I would need just a little bit more information.  Often when a doctor talks about low blood, it usualy means red blood cells but some of what you have posted also seems to indicate a low white cell count as well.\nIf the red count is the problem, a transfusion of packed red cells would, if the count is low enough, bring levels up quickly.  Iron supplements or an iron rich diet would help bring the red count up or help keep it up after transfusion if it is necessary.\nIf the white count is also low, things get a little more complicated.  A whole blood transfusion could be done, but units of whole blood would probably have to be specially collected from someone giving blood directly to the patient.  Most blood centers do not keep whole blood any more, they divide a unit into packed red blood cells, fresh frozen plasma, platelets and sometimes up to two other fractions so as to help as many people as possible from each unit of blood.  If a whole blood transfusion doesn't solve the problem, a bone marrow transplant may be the last choice.\nFirst thing to do is to find out just what the problem is, low blood count is a symptom not a disease in itself, something else is  causing this, you need to know what that is.  At first guess, I would suggest seeing a Hematologist, this is a doctor specializing in blood and dlood diseases.
892418
Risk factors\nThese factors may increase the risk of iron deficiency anemia:\n\nHeavy menstrual periods \nPregnancy \nA diet consistently low in iron \nA known or hidden source of bleeding within your body, such as an ulcer, a bleeding tumor, a uterine fibroid, a colon polyp, colorectal cancer, gastrointestinal bleeding or hemorrhoids \n\nThese groups of people may be at higher risk:\n\nWomen. Because their bodies store less iron and because they lose blood during menstruation, women in general are at greater risk of iron deficiency anemia. \n\nInfants and children. Infants who don't get enough iron in their milk or formula may risk deficiency. Children need extra iron during growth spurts, because iron is also important for muscle \ndevelopment. If your child isn't eating a healthy, varied diet, he or she may be at risk of anemia. \n\nVegetarians. Because vegetarians don't eat meat, they're at \ngreater risk of iron deficiency anemia. Iron that comes from grains and vegetables isn't absorbed by the body as well as is iron that comes from meat. \nIn healthy men and postmenopausal women, iron deficiency usually points to bleeding somewhere in the gastrointestinal tract.\n\nDonating blood — a source of blood loss — usually isn't a risk factor for iron deficiency anemia. However, some people first learn their hemoglobin is low, which indicates anemia, when they go to donate blood. Low hemoglobin may be a temporary problem remedied by eating more iron-rich foods. It may also be a warning sign of blood loss in your body. If you're told that you can't donate blood because of low hemoglobin, ask your doctor whether you should be concerned.\n\n\nhttp://www.mayoclinic.com/health/iron-deficiency-anemia/DS00323/DSECTION=4
8023
Most blood transfusions are of packed red cells and not serum/platelets or white cells.  Red cells have no nuclei/genetic material.  Blood type and rH factor are important and mismatch can yield a type of rejection.  The white cells are ultimately "rejected"   In someone with an inactive immune system (chemo patient) the blood can attack the recepient!
709950
Not that I know of.  I'm taking a guess here, but maybe you mean erythropoiesis?  From wikipedia:\n\nErythropoiesis is the process by which red blood cells (erythrocytes) are produced. In human adults, this usually occurs within the bone marrow; in humans with certain diseases, in fetuses and in some animals, erythropoeiesis also occurs outside the bone marrow, within the spleen, liver, or yolk sac.
957851
Yes.  Hematocrit represents the percentage of the blood volume that is composed of blood cells.  Mathematically, it is:\n\nHct = RBC x MCV\n\n(Hct = hematocrit, RBC = red blood cell count, MCV = mean corpuscular volume)\n\nIf your blood cells are really small (low MCV), then the hematocrit can be low even if you have the appropriate number of cells.\n\nCommon causes of microcytic anemia are iron deficiency, thalassemia, sideroblastic anemia, and lead poisoning.  In addition, various chronic disease processes can result in a microcytic anemia.
524028
If you want to decrease the RBC count in a person, the best way is to remove RBC from them, frequently.  I have been told that this is how they treat haemochromatosis; the patient donates blood very frequently.  It also decreases their iron stores.  In haemochromatosis, this is desirable.
975255
Honestly, you need to speak with your hematologist.  I also have itp, and after a bad spell in 2002 and transfusions followed by steroids, luckily, my levels have been fairly steady, in the 65k-90k range generally.  I'd make sure that you are taking regular vitamins and just speak with your Dr.  Good luck!
611944
It seems that this is a contradiction. Anaemia means a low Haemoglobin usually beacause of too few red blood cells, and Polycythaemia means too many red blood cells, reflected in a high Haemoglobin.
658465
Do you mean you are Thalassemia?\nI think it's not important so much to increase your Hemoglobin or Hematocrit to normal level all the time. If you are in healthy condition and take care yourself as your doctor advice, it's OK. People with anemia or other hematologic diseases have thier own adaptation to diseases and standard blood value level. Hope you have good health : )
68502
3.6 J ml-1 (°C)-1; at a haematocrit of 45 %
349574
You might try taking iron, it'll increase the number of red blood cells you have, and it's the red blood cells that carry oxygen to the rest of your body, but taking too much can cause problems so, I'd be careful about how much you take.