how do you evaluate the dermal toxicity of new drug?
80043
During preclinical tox testing, mice are the most common.\n\nAccording to the FDA guidance on woundcare products (from the CDER website):\nWhen preclinical studies or previous clinical experience suggest that a topical product might induce clinically significant dermatitis, irritancy or sensitivity testing in normal volunteers is recommended prior to trials in patients, since superimposed dermatitis is deleterious to wounds. The need for routine testing of the final formulation depends on the product, and sponsors are encouraged to discuss dermal toxicity testing with the appropriate Center before initiating the studies.\n\nHere is an exapmple of a Percutaneous Absorption Study for a topical drug product....\n\nToxicity/Irritation Tests:\nAcute Toxicity (LDn)\n14-Day Dermal Toxicity and Irritation in Mice\n7-Day Dermal Irritation in Guinea Pigs\nPrimary Skin Irritation in Guinea Pigs\nPrimary Eye Irritation in Rabbits\n13-Week Dermal Toxicity and Irritation Test in Rabbits\n91-Day Dermal Irritation and Toxicity Study
725901
This has got to be the most target-specific question I have ever seen here.\n\nI mean, a phone book check turned up nothing for you on this? Or a series of calls to a dermatogist's office to clarify?
771414
You don't know.  See a dermatologist for the best answers to your questions.
662227
I was given this drug when I had poison ivy, what are you taking it for???\nI would think it is dangerous for a baby, doesn't your doctor think so???\nI would get off of it as soon as possible if you are pregnant...\nIt is a strong drug...\nThey wouldn't let me have it very long...
192226
go to the dermatologist. he/she will burn it off.
711527
sounds like a nasty allergic reaction....\n\ndon't apply anything to your face-this includes allergy creams like hydrocortisone or benadryl creams. they could actually make the rash worse.\n\ntake oral bendadryl tablets. 1-2 of the 25mg tablets every 6 hours but no more than 4 doses in 24 hours.\n\nif after 24 hours of using the benadryl-the rash is still present and your face is still burning-then make an appt to see your dr. you might need antibiotics to get rid of the rash-sometimes allergic reactions are so severe, only antibiotics can treat them\n\nin the future don't use the zest again and you might want to check the label and compare it with other soaps-if they have the same ingredients then it's probably best to avoid them as well. i've found dove and ivory to work best on faces-they don't contain harsh perfumes or dyes and won't irritate your skin
436059
Try Webmd.com(USA), or just Google or use yahoo to search for the name of the drug and see what comes up. That usually leads you to a site that has the rundown on that drug
568055
It depends, where is the rash, and what does it look like? Could it be the side effects of the medication you are taking? Have you consulted your doctor?
356981
I've been reading up on this new research as well. I'm really excited about it and am curious to see how well it works in human trials. Unfortunately, it wouldn't be the first time something looks promising in lab animals but fails miserably in human trials.
173108
There will be no easy or fast way.  Some options:\n\nhttp://www.analoxusa.com/frame120tb.htm\n\nchemistry.uca.edu/Projects/Quant98/urea-ise-98.pdf \n\nhttp://biocompare.com/newtech/1522/QuantiChrom(tm)-Urea-Assay-Kit.html\n\nwww.springerlink.com/index/X07825U10H247238.pdf
857537
Your skin could be irritated by a new product you are using (shampoo, soap, scented pads, etc.)
1127515
Side effects at high intakes (50–200 mg per day) appear to be acne (in over 50% of people), increased facial hair (18%), and increased perspiration (8%). \nSignificant increases in testosterone levels in both men and women have been reported in some trials.caused cancer in animals.
4223
I would read the back of the product lable.  If this does not provide the answers, try contacting the company who makes it and ask.  Or, you can ask your docter/dermatologist.
130422
depends on the skin condition, need more info
10593
There are many products that will help. Go to a drugstore and ask the pharmacist. If it's very bad, you may need to see a dermatologist.
287102
check out side effects \nprobably heartburn
292916
You might want to try that new product they are selling at your local pharmacy 1st. It's in the skin care aisle and although I'm not sure what it's called, the packaging makes it pretty clear about what it does- it's worth a shot and may save you time, pain and money. Good luck!