can myelofibrosis affect the brain?
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When your body is forming blood in your liver and spleen, you may develop tumors elsewhere in your body, such as the lymph nodes, spinal cord and lungs. You may also feel confused because your liver isn't clearing toxins from your body efficiently, and these toxins affect the brain.
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Brain bleeds – bleeding between the brain tissue and skull or within the brain tissue itself – can cause brain damage and be life-threatening. Some symptoms include headache; nausea and vomiting; or sudden tingling, weakness, numbness or paralysis of face, arm or leg.
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Polycythemia vera (pol-e-sy-THEE-me-uh VEER-uh) is a type of blood cancer. It causes your bone marrow to make too many red blood cells. These excess cells thicken your blood, slowing its flow, which may cause serious problems, such as blood clots.
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['fatigue.', 'night sweats.', 'recurrent fevers.', 'weight loss.', 'itching.', 'bone pain, if your bone marrow is affected.', 'loss of appetite.', 'abdominal pain.']
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There are several secondary causes of polycythemia, including congenital heart disease, tumors in the kidney, hydronephrosis (or fluid swelling of the kidney), hyperadrenocorticism (Cushing's disease), various types of organ tumors, and certain types of bone marrow cancer.
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Other effects: Visual disturbances, mydriasis (pupil dilation), thrombocytopenia (low blood platelet count), anemia, alopecia (hair loss), arthralgia (consistent join pain), and lupus-like syndrome are found in some people.
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Unlike other neurological disorders, CMT usually isn't life-threatening, and it almost never affects the brain. It causes damage to the peripheral nerves — tracts of nerve cell fibers that connect the brain and spinal cord to muscles and sensory organs.
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In iron deficiency, low levels of hemoglobin in red blood cells mean that not enough oxygen can reach the brain. As a result, blood vessels in the brain can swell, causing pressure and headaches ( 12 ).
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We found that CFS patients as a group had significant reductions in cerebral blood flow across a number of brain in regions. However, those patients with no comorbid psychiatric diagnosis had more areas of reduced blood flow compared to controls than patients who did have comorbid psychiatric diagnoses.
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Headaches and Dizziness In iron deficiency, low levels of hemoglobin in red blood cells mean that not enough oxygen can reach the brain. As a result, blood vessels in the brain can swell, causing pressure and headaches ( 12 ).
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['Infections.', 'Head trauma.', 'Autoimmune diseases.', 'Exposure to certain drugs that treat cancer or severe infections.', 'Blood circulation problems.', 'Neurological disorders, such as multiple sclerosis.', "Disorders of the inner ear, such as Ménière's disease."]
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In severe cases, it can involve the kidneys, lymph system, brain and spleen. Symptoms include cough, weight loss and fatigue. Meningitis is a common complication when left untreated. Histoplasmosis – This infection almost always involves the lungs, although other organs may be affected.
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Mild traumatic brain injury may affect your brain cells temporarily. More-serious traumatic brain injury can result in bruising, torn tissues, bleeding and other physical damage to the brain. These injuries can result in long-term complications or death.
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['Aplastic anemia.', 'Cancer.', 'Certain medications, such as antiretroviral drugs for HIV infection and chemotherapy drugs for cancer and other conditions.', 'Chronic kidney disease.', 'Cirrhosis.', "Hodgkin's lymphoma (Hodgkin's disease)"]
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Leukemia, lymphoma, and multiple myeloma damage bone marrow. Also, cancers that spread to the bone or bone marrow may crowd out normal red blood cells.
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Radiation to the brain can cause these short-term side effects: Headaches. Hair loss. Nausea.
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['Leukemia or lymphoma.', 'Certain types of anemia.', 'Viral infections (chickenpox, hepatitis C, HIV, etc.)', 'Chemotherapy drugs.', 'Heavy alcohol consumption.']