how does sickle cell anemia affect spleen?
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Sickle cells can block the blood vessels leading out of the spleen. When this happens, blood stays in the spleen instead of flowing through it. This causes the spleen to get bigger, and the blood counts to fall. This is called a splenic sequestration (SPLEN ik seh ques TRAY shun) crisis, or simply “spleen crisis.”
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6. Small Spleen. Adults with small spleen usually have homozygous sickle cell disease which causes chronic splenic infarction. The spleen can be densely calcified and small on radiographs and CT (Figure 11).
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Sickle cell anemia is the result of a point mutation, a change in just one nucleotide in the gene for hemoglobin. This mutation causes the hemoglobin in red blood cells to distort to a sickle shape when deoxygenated. The sickle-shaped blood cells clog in the capillaries, cutting off circulation.
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In pregnancy, it is important for blood cells to be able to carry oxygen. With sickle cell anemia, the abnormal red blood cells and anemia may result in lower amounts of oxygen going to your developing baby. This can slow down the baby's growth.
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When red blood cells sickle, they break down prematurely, which can lead to anemia. Anemia can cause shortness of breath, fatigue, and delayed growth and development in children. The rapid breakdown of red blood cells may also cause yellowing of the eyes and skin, which are signs of jaundice.
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Periodic episodes of pain, called pain crises, are a major symptom of sickle cell anemia. Pain develops when sickle-shaped red blood cells block blood flow through tiny blood vessels to your chest, abdomen and joints. Pain can also occur in your bones.
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Answer: (4) The spleen plays an important role in the red blood cells also known as aserythrocytes and the digestive system. Old and damaged RBC's are destroyed in the spleen and It is known as the RBCs Graveyard.
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Red blood cells look like round discs. But in sickle cell disease, they're shaped like sickles, or crescent moons, instead. These sickle shaped cells get stuck together and block small blood vessels. This stops blood from moving as it should, which can lead to pain and organ damage.
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Many of the complications or health problems caused by sickle cell disease are caused by organ damage or inflammation. Sickle cells also die sooner than normal red blood cells. Not having enough healthy red blood cells causes anemia, which can make you feel tired or weak because there is less oxygen in your body.
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The spleen normally removes these bodies from the RBCs; however, Howell-Jolly bodies can be observed on a Wright-stained peripheral blood smear post-splenectomy or when the spleen is not functioning properly. Howell-Jolly bodies may also be seen in hemolytic anemias such as sickle cell anemia.
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Sickle cell anemia is a disorder of the red blood cells which causes blood vessels to become blocked. Sickle cell anemia in pregnant women can cause complications including premature birth or miscarriage. The risk of the baby inheriting the disease is increased if both parents carry the gene.
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Organ damage. Sickle cells that block blood flow to organs deprive the affected organs of blood and oxygen. In sickle cell anemia, blood is also chronically low in oxygen. This lack of oxygen-rich blood can damage nerves and organs, including your kidneys, liver and spleen, and can be fatal.
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Your spleen's main function is to act as a filter for your blood. It recognizes and removes old, malformed, or damaged red blood cells. When blood flows into your spleen, your spleen performs "quality control"; your red blood cells must pass through a maze of narrow passages.
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The sickle cells die early, which causes a constant shortage of red blood cells. Also, when they travel through small blood vessels, they get stuck and clog the blood flow. This can cause pain and other serious problems such infection, acute chest syndrome and stroke.
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The signs and symptoms of sickle cell disease are caused by the sickling of red blood cells. When red blood cells sickle, they break down prematurely, which can lead to anemia. Anemia can cause shortness of breath, fatigue, and delayed growth and development in children.
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Having sickle cell disease means a lifelong battle against the health problems it can cause, such as pain, infections, anemia, and stroke. But many people are able to have a very good quality of life by learning to manage the disease.
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['Feeling tired, weak or short of breath, usually because of anemia.', 'Pain or fullness below your ribs on the left side, due to an enlarged spleen.', 'Easy bruising.', 'Easy bleeding.', 'Excessive sweating during sleep (night sweats)', 'Fever.']