does omeprazole cause vitamin b12 deficiency?
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The chronic use of proton pump inhibitors such as omeprazole (Prilosec) is fairly common in medical practice especially for gastroesophageal reflux disease (GERD) or in patients at increased risk of peptic ulcer disease (PUD), but has been associated with causing vitamin B12 deficiency.
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Oral vitamin B-12 is safe to take at recommended doses for healthy people. Injectable vitamin B-12, which is used to treat significant deficiencies, can cause the following side effects: mild diarrhea. itching.
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Common side effects include headaches, diarrhoea and stomach pain. These tend to be mild and go away when you stop taking the medicine. If you're self-treating with omeprazole, do not take it for longer than 2 weeks without checking with a doctor. Omeprazole is also called by the brand names Losec and Losec MUPS.
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Omeprazole is usually well tolerated by dogs and cats. However, it can sometimes cause GI upset (poor appetite, colic, nausea, vomiting, flatulence, and diarrhea). Use of omeprazole has been associated with urinary tract infections and protein in the urine. Omeprazole may cause increased liver enzymes on blood tests.
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Large amounts of folic-acid supplements don't interfere with vitamin B12 absorption, but folic acid can mask the symptoms of a vitamin B12 deficiency. Folic acid can correct a condition called megaloblastic anemia, which is caused by low vitamin B12 levels.
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The co-administration of omeprazole and grapefruit juice decreases the formation of omeprazole sulfone (mediated by CYP3A4) but does not inhibit the formation of 5-hydroxyomeprazole, which is mediated by CYP2C19. Grapefruit juice may inhibit the metabolism of pimozide resulting in increased concentrations of pimozide.
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In recent years, the use of proton pump inhibitors (PPI), especially omeprazole, has been associated with development of chronic kidney disease (CKD). These drugs are widely used worldwide. Although some studies have found an association between the use of PPI and the onset of acute renal failure and CKD.
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B vitamins Chapped lips are a common symptom of deficiencies, especially in folate (vitamin B9), riboflavin (vitamin B2), and vitamins B6 and B12 ( 11 , 12 , 13 , 14 ).
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What should I avoid while taking omeprazole? This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.
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Popular Antacids Could Cause Vitamin Deficiency. Medications like Prilosec and Nexium could give patients a Vitamin B12 deficiency if they're taken for more than two years, a new study shows. People taking acid-inhibiting medications, such as Prilosec, Zantac, Pepcid, or Nexium, could be short on Vitamin B12.
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Omeprazole may also make you feel dizzy or sleepy. Some people might find it difficult to fall asleep. It may also cause an itchy or lumpy skin rash, or make your feet or ankles swell. Talk to your doctor or pharmacist if the side effects bother you or don't go away.
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Omeprazole can make you feel dizzy, sleepy, or get blurred vision. If this happens to you, do not drive, cycle or use machinery or tools until you feel better.
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Conclusions: Chronic, persistent cough may occur as an adverse effect of omeprazole therapy. Clinicians must be aware of this adverse effect to avoid useless and costly tests.
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Symptoms of a Deficiency A deficiency in B12 or folate may take months or years to become evident, and may lead to symptoms such as fatigue, muscle weakness, diarrhea, difficulty concentrating, forgetfulness, sleeplessness, irritability, and mood swings.
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Common risk factors for low vitamin B12 in seniors include: Low levels of stomach acid, which can be due to weakening of the stomach lining, or to medications that reduce stomach acid. Medications such as metformin (prescribed for diabetes), which interferes with vitamin B12 absorption.
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Older adults and people with digestive tract conditions that affect absorption of nutrients also are susceptible to vitamin B-12 deficiency. Left untreated, a vitamin B-12 deficiency can lead to anemia, fatigue, muscle weakness, intestinal problems, nerve damage and mood disturbances.
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Vitamin B12 Shots Are Very Effective An untreated vitamin B12 deficiency can lead to neurological problems or pernicious anemia, which occurs when your body doesn't have enough B12 to produce the amount of red blood cells it needs ( 16 ). Vitamin B12 shots are the most common way to prevent or treat a deficiency.