do dendritic cells activate b cells?
527717
Dendritic cells have been shown to have a role in T-cell and B-cell functions, including proliferation and antibody isotype switching. ... CD40 expression on DC and B cells is well established and it has been assumed that these cells then interact with CD40 ligand (CD40L) on activated T cells.
920681
Activated B cells express CD28/B7-independent costimulatory activity. ... We report here that activation of B cells induces a novel costimulatory activity for induction of T cell proliferation, which is independent of the CD28/B7 costimulatory pathway.
134665
Naive B cells circulate in the lymph and secondary organs until they encounter antigen in the B-cell follicles. ... Most soluble protein antigens bear single epitopes that can still trigger an immune response specific for that epitope.
1080974
Abstract. Dendritic cells are the most efficient antigen-presenting cells. ... Indeed, dendritic cells are the only antigen-presenting cells that induce the activation of resting T cells, both in vitro and in vivo. Thus, dendritic cells initiate adaptive immune responses and determine tolerance.
1249021
B cells differentiate into plasma cells that produce antibody molecules closely modeled after the receptors of the precursor B cell. ... clonal selection of a B cellClonal selection of a B cell. Activated by the binding of an antigen to a specific matching receptor on its surface, a B cell proliferates into a clone.
1378089
In an inflammatory environment, autoreactive T cells are activated initially by dendritic cells (DCs). Like macrophages and B cells, DCs are professional antigen-presenting cells (APCs).
402856
Dendritic cells (DCs) represent a heterogeneous family of immune cells that link innate and adaptive immunity. The main function of these innate cells is to capture, process, and present antigens to adaptive immune cells and mediate their polarization into effector cells (1).
768743
Unlike T cells that recognize digested peptides, B cells recognize their cognate antigen in its native form. The B cell receptor used in recognition can also be secreted to bind to antigens and initiate multiple effector functions such as phagocytosis, complement activation, or neutralization of receptors.
1256616
Dendritic cells have been shown to have a role in T-cell and B-cell functions, including proliferation and antibody isotype switching. However, the molecules involved in these interactions are unknown. ... Moreover, CD40 has been shown to have a role in B-cell survival12 but it was assumed to be via T cells.
694202
B memory cells are there and they maintain persistence specific elevated antibodies life time. if new antigen trigger is there stimulated B cells cause production of antibodies.so in immunocompetent individual s b cells produce antibodies for life time.
1027415
The three types of lymphocytes are T cells, B cells, and natural killer cells. The T cells destroy pathogens in a specific manner and activate B cells to produce antigen-specific antibodies. Phagocytes can be either macrophages, neutrophils, monocytes, dendritic cells or mast cells.
567921
Granulocytes acquire antigen-presenting cell (APC) features via bystander activation from neighboring professional APCs stimulating T cells. Antigen presentation initiated by dendritic cells (DCs) or other professional APCs leads to stimulation of T cells ...
1318262
The first antibodies made by a newly formed B cell are not secreted. Instead, they are inserted into the plasma membrane, where they serve as receptors for antigen. ... Each B cell produces a single species of antibody, each with a unique antigen-binding site.
1310512
B cells respond to pathogens and other cells from outside the body in the blood and lymph. Most B cells fight infections by making antibodies. ... Phagocytes are white blood cells that engulf targeted antigens by phagocytosis. As the antigen is on the outside of a pathogen, the pathogen is destroyed by this process.
720524
Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system. ... Once activated, they migrate to the lymph nodes where they interact with T cells and B cells to initiate and shape the adaptive immune response.
884911
B cell activation requires two distinct signals, and results in B cell differentiation into memory B cells or plasma cells. ... Upon binding to the BCR, the antigen is internalized by receptor-mediated endocytosis, digested, and complexed with MHC II molecules on the B cell surface.
1230825
Helper T cells do not directly kill infected cells, as cytotoxic T cells do. Instead they help activate cytotoxic T cells and macrophages to attack infected cells, or they stimulate B cells to secrete antibodies. Helper T cells become activated by interacting with antigen-presenting cells,…