are selective cox-2 inhibitors nephrotoxic?
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As further evidence of an important role for COX-2 in regulation of renal hemodynamics and renin production, acute ischemic renal insufficiency and hyperkalemia/type IV renal tubular acidosis have been reported as acute nephrotoxic effects of COX-2 inhibitors, especially in the older adults (88,92–95).
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Further, prescription NSAIDs have been associated with improvements in nocturia and other urinary symptoms in clinical investigations (9–13). In contrast, 2 large studies of men reported associations between NSAID use and increased risk of acute urinary retention (7), nocturia, and benign prostatic hyperplasia (14).
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Because NSAIDs block the production of the COX-1 and COX-2 prostaglandins, renal side effects are not uncommon, occurring in approximately 1% to 5% of NSAID users. By inhibiting COX-2's natriuretic effect, thereby increasing sodium retention, all NSAIDs carry with them the consequent risk of increased fluid retention.
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Mayo Clinic researchers have found that taking nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen may prevent or delay benign prostatic hyperplasia, an enlarged prostate which can cause urinary symptoms in men as they age such as frequent urination, trouble starting urination, awakening ...
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What are COX-2 inhibitors, and how do they work? COX-2 inhibitors are a subclass of nonsteroidal antiinflammatory drugs (NSAIDs). NSAIDs work by reducing the production of prostaglandins, chemicals that promote inflammation, pain, and fever.
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COX-2 inhibitors are a subclass of nonsteroidal antiinflammatory drugs (NSAIDs). NSAIDs work by reducing the production of prostaglandins, chemicals that promote inflammation, pain, and fever.
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NSAIDs help ease pain and inflammation. But if you have high blood pressure, heart failure, or kidney disease, you should not take an NSAID. And you should not take any drugs that have ibuprofen or another NSAID in them.
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What are COX-2 Inhibitors (e.g. Vioxx, Celebrex and Bextra)? The main brands of COX-2 inhibitor drugs currently on the market are Celebrex and Bextra (since the Vioxx recall). COX-2 inhibitors are a newer type of NSAID that block the COX-2 enzyme at the site of inflammation.
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Many COX-2-specific inhibitors have been removed from the US market. As of December 2011, only Celebrex (generic name is celecoxib) is still available for purchase in the United States.
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Ibuprofen (Advil, Motrin) The Bad: Can impair kidney function, more so if taken before or during a run. (NSAIDs inhibit blood-flow to the kidneys. Kidney circulation can also be suppressed by dehydration.
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Even more alarming, the study noted end-stage kidney failure rates were twice as high among PPI users. More studies are underway to evaluate the risk of kidney problems caused by Nexium and Prilosec. Previous studies have linked Prilosec and Nexium use with Acute Interstitial Nephritis and Acute Kidney Injury.
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Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis.
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Several drugs, such as cimetidine, trimethoprim, corticosteroids, pyrimethamine, phenacemide, salicylates and active vitamin D metabolites, have been reported to increase plasma creatinine without influencing its glomerular filtration.
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Check with your doctor to be sure you can use these medicines safely, particularly if you have kidney disease. Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis.
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COX-2 inhibitors are NSAIDs that selectively block the COX-2 enzyme and not the COX-1 enzyme. Blocking this enzyme impedes the production of prostaglandins by the COX-2 which is more often the cause the pain and swelling of inflammation and other painful conditions.
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Is Celebrex or Ibuprofen more effective? Celebrex is known as a selective COX-2 inhibitor. While it is still an NSAID like ibuprofen, Celebrex only blocks COX-2, as opposed to ibuprofen, which blocks both COX-1 and COX-2.