can omeprazole cause magnesium deficiency?
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[3-2-2011] The U.S. Food and Drug Administration (FDA) is informing the public that prescription proton pump inhibitor (PPI) drugs may cause low serum magnesium levels (hypomagnesemia) if taken for prolonged periods of time (in most cases, longer than one year).
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Iron deficiency anemia - Induced by long-term ingestion of omeprazole. Omeprazole is known to cause prolonged suppression of gastric acid secretion. Since acid plays an important role in the absorption of food iron (nonheme iron), this drug may lead to an iron deficiency state.
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Adults—20 milligrams (mg) once a day before a meal. Your doctor may want you to take omeprazole for more than 8 weeks for certain conditions. Children 1 year of age and older—Dose is based on body weight and must be determined by your doctor.
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The ability of PPIs to alter bone mass an/or cause osteoporosis is also unclear. In animal studies the PPI omeprazole reduced bone density [68,69]. In contrast, some human studies report no effect of PPIs to cause alterations in bone turnover and/or bone density as well as no effect at causing osteoporosis [67].
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Mechanism A suggested mechanism for omeprazole to cause erectile dysfunction is the interference with the metabolism op hormones. Omeprazole was seen to induce the enzyme CYP3A4, in high serum levels (high dosed or in a specific population with a polymorphism for poor omeprazole metabolism).
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Summary: The chronic use of proton pump inhibitors such as omeprazole (Prilosec) is fairly common in medical practice especially for gastroesophageal reflux disease (GERD) or in patients at increased risk of peptic ulcer disease (PUD), but has been associated with causing vitamin B12 deficiency.
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Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough.
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Prilosec (omeprazole) is a proton pump inhibitor that treats severe stomach acid-related conditions like GERD. Common Prilosec side effects include headache, stomach pain and nausea. Long-term Prilosec use has been linked to kidney damage, bone fractures and other dangerous side effects.
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['Kidney injury, damage or failure.', 'Acute Interstitial Nephritis (AIN)', 'Bone fracture of the hip, wrist or spine.', 'Vitamin B-12 deficiency.', 'Clostridium difficile-associated diarrhea (caused by intestinal infection)', 'Lupus Erythematosus.', 'Low magnesium levels.']
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Conclusions: Chronic, persistent cough may occur as an adverse effect of omeprazole therapy. Clinicians must be aware of this adverse effect to avoid useless and costly tests.
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According to the Office of Dietary Supplements, symptoms of magnesium overdose may include: diarrhea. nausea and vomiting. lethargy.
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['Muscle Twitches and Cramps. Share on Pinterest. ... ', 'Mental Disorders. Mental disorders are another possible consequence of magnesium deficiency. ... ', 'Osteoporosis. ... ', 'Fatigue and Muscle Weakness. ... ', 'High Blood Pressure. ... ', 'Asthma. ... ', 'Irregular Heartbeat.']
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Esomeprazole Magnesium delayed-release capsules are a proton pump inhibitor indicated for treatment of gastroesophageal reflux disease (GERD), risk reduction of nonsteroidal anti-inflammatory drug (NSAID)-associated gastric ulcer, and pathological hypersecretory conditions, including Zollinger-Ellison Syndrome.
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Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, fever, blood/mucus in your stool. Rarely, proton pump inhibitors (such as omeprazole) have caused vitamin B-12 deficiency. The risk is increased if they are taken every day for a long time (3 years or longer).
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A major cause of poor digestion is dehydration. Lack of water, calcium and magnesium can cause ulcers, gastritis and acid reflux because the stomach doesn't have enough H2O to produce digestive acid.
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Omeprazole is usually well tolerated by dogs and cats. However, it can sometimes cause GI upset (poor appetite, colic, nausea, vomiting, flatulence, and diarrhea). Use of omeprazole has been associated with urinary tract infections and protein in the urine. Omeprazole may cause increased liver enzymes on blood tests.
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Omeprazole can make you feel dizzy, sleepy, or get blurred vision. If this happens to you, do not drive, cycle or use machinery or tools until you feel better.