does gabapentin cause renal failure?
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Background: Gabapentin is frequently used as an analgesic in patients with chronic kidney disease. Although gabapentin is well known for its favorable pharmacokinetics, it is exclusively eliminated renally, and patients with chronic kidney disease are at risk for toxicity.
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Conclusion. Chronic administration of gabapentin and carbamazepine may cause increase in neurodegenerative changes in the adult brain.
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There was no evidence that gabapentin affected bone strength or BMD in this study. However, the drug was associated with deterioration of the cancellous bone microstructure owing to decreased bone formation and increased bone resorption after 12 weeks, which may lead to a long-term effect on bone strength or BMD.
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Therefore, based on the case report and reported hyperglycemia in clinical trials, it seems gabapentin can cause mild blood glucose disturbances for an unknown mechanism of action.
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Drugs that may cause interstitial nephritis include penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs and rifampicin. There are a number of drugs that cause direct toxicity to the renal tubules (acute tubular necrosis) - eg, aminoglycosides, amphotericin and ciclosporin.
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Gabapentin-Induced Urinary Incontinence: A Rare Side Effect in Patients with Neuropathic Pain.
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In summary, we can conclude that although it happens infrequently, gabapentin may cause myotoxicity, rhabdomyolysis and renal failure even in patients whose renal function was previously normal.
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Gabapentin is in a class of medications called anticonvulsants. Gabapentin treats seizures by decreasing abnormal excitement in the brain. Gabapentin relieves the pain of PHN by changing the way the body senses pain.
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Gabapentin may cause other long-term effects, including memory loss, weakened muscles, and respiratory failure.
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While sedation and ataxia can occur with the use of gabapentin, there have been no reported serious safety issues in animals. 4 In our experience, other possible side effects include gastrointestinal distress-such as loss of appetite, vomiting and diarrhea-and increased anxiety or agitation.
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Various classes of antibiotics can harm the kidneys in different ways. Aminoglycosides such as tobramycin can cause toxicity in “renal tubular cells,” which are more sensitive to the toxic effects of drugs because their role in kidney filtration exposes them to high levels of toxins.
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Hypertension is one of the most common chronic diseases and public health problems worldwide. Our previous study indicated that oral gabapentin can markedly attenuate blood pressure in chronic kidney disease-induced hypertension.
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2) Gabapentin Gabapentin is known to cause lower leg swelling. In studies on patients with shingles, swelling appeared in 8% of the patients taking gabapentin.
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However, they have been associated with gastrointestinal complications such as gastric ulcer formation. Gabapentin is a drug that is used in the treatment of epilepsy, anxiety, depression and neuropathic pain.
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Gabapentin, a water-soluble amino acid, is eliminated unchanged by the kidneys and there is no appreciable metabolism by the liver. However, there are a few descriptions of gabapentin-related liver toxicity in the medical literature.
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Of all the drugs used in anesthesia, muscle relaxants are among the most affected by renal failure. The uremic state is associated with a variety of derangements which predispose for adverse drug reactions.
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Some of the common side effects of gabapentin can include drowsiness, dizziness, fatigue, tremors, weight gain, nervousness and dry mouth. People on gabapentin may also experience double vision and other vision changes.