why ldh is high in hemolytic anemia?
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Hemolysis may also lead to elevated LDH and bilirubin. LDH is present in red cells and hemolysis causes release into the plasma. Bilirubin is a breakdown product of hemolglobin and becomes elevated as hemoglobin is released.
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High blood pressure and high blood sugar cause the kidney damage that brings on anemia. If your doctor has prescribed you medication for either high blood pressure or high blood sugar, it's important that you take it. A good diet and regular exercise also help.
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Causes. A high hemoglobin count occurs most commonly when your body requires an increased oxygen-carrying capacity, usually because: You smoke. You live at a high altitude and your red blood cell production naturally increases to compensate for the lower oxygen supply there.
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Conditions that may lead to hemolytic anemia include inherited blood disorders such as sickle cell disease or thalassemia, autoimmune disorders, bone marrow failure, or infections. Some medicines or side effects to blood transfusions may cause hemolytic anemia.
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Lactate dehydrogenase (LDH) is present in cells. When cells are damaged, they are released into the bloodstream. Therefore, LDH levels in the blood are usually used as indicators of tissue damage. Serum LDH levels also have momentous significance in cancer diagnosis due to tissue destruction caused by tumor growth.
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Pleural fluid LDH levels greater than 1000 IU/L suggest empyema, malignant effusion, rheumatoid effusion, or pleural paragonimiasis. Pleural fluid LDH levels are also increased in effusions from Pneumocystis jiroveci (formerly, P carinii) pneumonia.
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MARKED HEMOLYSIS- increase Bilirubin and affect gamma-Glutamyl-Transferase (GGT), Alkaline Phosphatase (ALP), Total CO2, Albumin, Creatine kinase (CK), Total Protein, Lactate dehydrogenase (LD), Triglycerides, Glucose, Phosphorus, Uric Acid and Bile Acid values.
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The lactate dehydrogenase (LDH) test looks for signs of damage to the body's tissues. LDH is an enzyme found in almost every cell of your body, including your blood, muscles, brain, kidneys, and pancreas. The enzyme turns sugar into energy. The LDH test measures the amount of LDH in your blood or other body fluid.
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Hemoglobin is broken down into a compound called bilirubin. High levels of bilirubin in the bloodstream may be a sign of hemolytic anemia. High levels of this compound also occur with some liver and gallbladder diseases. Thus, you may need liver function tests to find out what's causing the high bilirubin levels.
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Red Blood Cell Disorders Men have slightly higher levels of hemoglobin, and this is thought to be due to the stimulatory effect of androgens on the bone marrow.
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Serum LDH is commonly elevated in lympho-proliferative disorders. In patients with non-Hodgkin's lymphoma (NHL), LDH levels are of prognostic importance and thus can be used to monitor treatment response and recurrence, if any.
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A high red blood cell count can result from a condition that limits your oxygen supply or a condition that directly increases red blood cell production.
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Elevated levels may indicate liver damage or disease. Higher than normal levels of direct bilirubin in your blood may indicate your liver isn't clearing bilirubin properly. Elevated levels of indirect bilirubin may indicate other problems.
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Large amounts of vitamin C (ascorbic acid) may lower LDH levels. Alcohol, anesthetics, aspirin, narcotics, and procainamide may raise LDH levels. Strenuous exercise may also raise LDH levels. Ask your doctor about any medications you should avoid before the test.
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Elevated levels may indicate liver damage or disease. Higher than normal levels of direct bilirubin in your blood may indicate your liver isn't clearing bilirubin properly.
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doses of folic acid and therefore in deciding whether megaloblastic anaemia is partially or completely due to folic acid deficiency. Elevation of plasma lactate dehydrogenase concen- tration (LDH) is known to occur in patients with megaloblastic anaemia.
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High ALP usually means that either the liver has been damaged or a condition causing increased bone cell activity is present. If other liver tests such as bilirubin, aspartate aminotransferase (AST), or alanine aminotransferase (ALT) are also high, usually the increased ALP is caused by liver damage or disease.