are ssris safer than benzos?
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In general, antidepressants, especially selective serotonin reuptake inhibitors (SSRIs) such as sertraline (Zoloft), are as effective as and safer than benzodiazepines for the long-term treatment of panic disorder and generalized anxiety.
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In a randomized, double-blind study comparing the two drugs for the treatment of panic disorder, Paxil and Zoloft were found to be equally effective; however, Zoloft was slightly better tolerated, and patients did better when discontinuing the drug.
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Like other SSRIs, Lexapro affects your brain by blocking the reuptake of serotonin. Serotonin is a neurotransmitter known for its effects on mood. SSRI drugs are among the safest classes of antidepressants, so they're often doctors' first choice for treating depression.
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Doctors often start by prescribing an SSRI. These drugs are considered safer and generally cause fewer bothersome side effects than other types of antidepressants. SSRIs include citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil, Pexeva), sertraline (Zoloft) and vilazodone (Viibryd).
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Buspar vs. Zoloft differences. Buspar (buspirone) and Zoloft (sertraline) are both drugs used to treat anxiety. The main difference is that Zoloft belongs to a drug class of antidepressants called SSRIs (selective serotonin reuptake inhibitors), so researchers know how Zoloft works in treating anxiety.
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Ativan and Xanax are both benzodiazepines used for the treatment of anxiety, and both are equally effective for this use. The differences are: Xanax has a quicker onset of effect, but a shorter duration of action (4 to 6 hours) compared with Ativan's 8 hours.
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Overall, citalopram appears to be the best-tolerated SSRI, followed by fluoxetine, sertraline, paroxetine, and fluvoxamine. The latter 2 drugs are associated with the most side effects and the highest discontinuation rates because of side effects in clinical trials.
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Main similarities and differences, which explain why SSRIs are more commonly prescribed than TCAs in the treatment for depression: SSRIs and TCAs have similar efficacy for the treatment of depression. SSRIs have fewer anticholinergic and cardiovascular side effects. TCA have fewer sexual and gastrointestinal side ...
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The selective serotonin reuptake inhibitors (SSRIs) and the newer antidepressants buproprion, mirtazapine, moclobemide, and venlafaxine (a selective norepinephrine reuptake inhibitor or SNRI) are all relatively safe in the elderly.
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SSRIs approved by the Food and Drug Administration (FDA) for the treatment of panic disorder include fluoxetine (Prozac), paroxetine (Paxil, Pexeva) and sertraline (Zoloft).
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Paxil (paroxetine) is effective for treating depression and anxiety, but causes more unwanted side-effects than other medicines that work like it. Improves mood and helps you relax. Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.
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Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines. Improves mood. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.
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Lexapro and Zoloft are both SSRI medications, but their indications vary (see above). Because they are in the same category, they have many of the same drug interactions and side effects.
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Beach and colleagues2 emphasize that SSRIs, including fluoxetine and paroxetine, are not statistically significantly associated with QT prolongation, as indicated by comprehensive, prospective studies regarding the corrected QT (QTc) interval.
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SSRIs increase levels of serotonin in the brain by preventing the reuptake of serotonin by nerve cells. They are often selected as a first-line drug treatment for depression due to effectiveness and a lower risk of side effects compared to older antidepressants.
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The SSRIs can cause insomnia and worsen sleep quality, but bupropion is surprisingly more favorable for sleep. Although it is activating in the daytime, bupropion causes no more insomnia than the SSRIs and has neutral or positive effects on sleep architecture.
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Although SSRIs are the current frontline treatment for depression, MAOIs (monoamine oxidase inhibitors) were the first antidepressants developed. They are typically more potent than SSRIs because they affect more neurotransmitters, and they can cause more side effects.