what are the risks of estrogen therapy?
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Stroke, blood clots, and heart attack. Women who took either combined hormone therapy or estrogen alone had an increased risk of stroke, blood clots, and heart attack (1, 2). For women in both groups, however, this risk returned to normal levels after they stopped taking the medication (3, 4).
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Why does HRT increase breast cancer risk? HRT helps relieve menopausal symptoms by increasing oestrogen levels. It's not fully understood why HRT increases the risk of breast cancer, but research indicates that the higher levels of oestrogen help some breast cancers to grow.
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Common side effects include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, and hair loss. Other side effects have been reported with estrogen and/or progestin therapy including increase or decrease in weight.
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These include an increased risk of breast cancer. The use of progestins with OSPHENA therapy was not evaluated in the clinical trials. Clinical surveillance of all women using OSPHENA is important.
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Side effects of the GnRH agonists are signs and symptoms of hypoestrogenism, including hot flashes, headaches, and osteoporosis. In patients under long-term therapy, small amounts of estrogens could be given back (“add-back regimen”) to combat such side effects and to prevent bone wastage.
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Estrogen-only HRT also can increase the risk of ovarian cancer. The higher breast cancer risk from using HRT is the same for so-called "bioidentical" and "natural" hormones as it is for synthetic hormones. "Bioidentical" means the hormones in the product are identical to the hormones your body produces.
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Estradiol Warnings In one study, women who took estrogens (such as estradiol) by mouth with progestin had a higher risk of heart attacks, stroke, blood clots, breast cancer, and dementia. Women who use topical estradiol alone or with progestin may also have a higher risk of developing these conditions.
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['Infertility. Estrogen is one of the hormones your body uses to produce sperm. ... ', 'Gynecomastia. Increased estrogen can cause more breast tissue to develop than normal. ... ', 'Erectile dysfunction (ED). ... ', 'Slowed growth. ... ', 'Epiphyseal closure.']
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Low estrogen levels can impact many aspects of a woman's overall health and wellbeing, including her physical, emotional, and sexual health. They may also increase a woman's risk of serious conditions, including heart disease, osteoporosis (softening of bone tissue), and obesity.
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['Tiredness. You may feel more tired when you are taking hormone therapy. ... ', 'Digestive system problems. Hormone therapy can cause a few problems with your digestive system. ... ', 'Menopausal symptoms. ... ', 'Hair thinning. ... ', 'Muscle and bone changes. ... ', 'Weight gain. ... ', 'Headaches. ... ', 'Memory problems.']
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In the largest clinical trial to date, hormone replacement therapy that consisted of an estrogen-progestin pill (Prempro) increased the risk of certain serious conditions, including: Heart disease. Stroke. Blood clots.
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Risks of tibolone are similar to the risks of HRT, and include an increased risk of breast cancer and strokes. Talk to your GP about the risks and benefits of tibolone if you're considering taking it.
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Every woman is at a small risk of getting endometrial cancer (cancer of the lining of the womb), whether or not HRT is used. The risk of cancer of the lining of the womb increases with the duration of treatment. Breakthrough bleeding or spotting may occur during the first few months of using Ovestin.
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Side effects of HRT As with any medicine, HRT can cause side effects. But these will usually pass within 3 months of starting treatment. Common side effects include: breast tenderness.
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Low estrogen levels can interfere with sexual development and sexual functions. They can also increase your risk of obesity, osteoporosis, and cardiovascular disease.
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Breast cancer treatments like chemotherapy, radiation, ovary removal, and antiestrogen therapy can bring on what's called chemical menopause. And with it comes lower estrogen levels and symptoms like hot flashes. Hot flashes that result from breast cancer treatment can be more frequent and severe than natural ones.
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Just about all treatments for breast cancer cause some type of side effects. Surgery can cause pain and lymphedema. Hormonal therapy can cause hot flashes, joint pain, and bone thinning. Chemotherapy can cause hair loss, diarrhea, neuropathy, fatigue, and mouth sores.