who multiple myeloma diagnostic criteria?
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['Clonal bone marrow plasma cells ≥10% or bony or extramedullary plasmacytoma (confirmed by biopsy)', 'One or more myeloma-defining events.']
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['Amyloidosis (buildup of abnormal proteins in your organs)', 'Dehydration.', 'Hepatitis B.', 'Hepatitis C.', 'HIV/AIDS.', 'Monoclonal gammopathy of undetermined significance (MGUS)', 'Multiple myeloma.']
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This definition was subsequently expanded to include three additional results, defined by the International Myeloma Working Group (IMWG), which indicate a high risk of progression: Bone marrow plasma cell (BMPC) percentage ≥60% Involved: uninvolved free light chain (FLC) ratio >100.
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Overview. High-dose chemotherapy and autologous stem cell transplantation (ASCT) is an integral component of the overall management of patients with multiple myeloma who are 65 years of age or younger.
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Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone within the bone marrow. While the cause of myeloma is not known, interleukin 6 may play a role in driving myeloma cell proliferation. Waldenstrom's macroglobulinemia (WM) is a proliferative disease of B-lymphocytes.
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Though multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) have overlapping epidemiologic features and originate from mature B cells, the simultaneous occurrence of both cancers is rare, and data on clinical outcomes and the management of these concurrent disease are limited.
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The overall 5-year survival rate for people with multiple myeloma is 54%. For the 5% of people who are diagnosed at an early stage, the 5-year survival rate is almost 74%. If the cancer has spread to a distant part of the body, the 5-year survival rate is 51%.
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Life Expectancy In general, 50.7%, or about half the people diagnosed with multiple myeloma were alive 5 years later. That's because it's often difficult to diagnose multiple myeloma until it's progressed. But the earlier you catch it, the better your chances are. Early-stage diagnosis.
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['Age. The risk of developing multiple myeloma goes up as people get older. ... ', 'Gender. Men are slightly more likely to develop multiple myeloma than women.', 'Race. Multiple myeloma is more than twice as common in African Americans than in white Americans. ... ', 'Family history. ... ', 'Obesity. ... ', 'Having other plasma cell diseases.']
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The goals of treatment are to eliminate myeloma cells, control tumor growth, control pain, and allow patients to have an active life. While there is no cure for multiple myeloma, the cancer can be managed successfully in many patients for years.
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What is the outlook for stage 3 multiple myeloma? The average survival rate for stage 3 multiple myeloma is 29 months. However, significant medical advances are helping to increase survival rates.
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Although MRI scans can sometimes show enough evidence to make a diagnosis, it is still unusual to diagnose MS from just a single episode of symptoms. The most commonly used guidance for making a diagnosis of MS is called the McDonald criteria.
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Multiple myeloma, lymphoma, and leukemia are all types of cancer that start in your blood cells. Doctors often call them blood cancers. While these three types of cancer are alike in some ways, they affect different parts of your body.
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Survival rates are based on comparing people with multiple myeloma to their peers who don't have cancer. According to the American Cancer Society (ACS), these are the average survival rates by stage: Stage 1: 62 months, which is approximately five years. Stage 2: 44 months, which is approximately three to four years.
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This can cause the blood to thicken and keep the bone marrow from making enough healthy blood cells. Multiple myeloma cells also damage and weaken the bone. Plasma cell neoplasms are diseases in which abnormal plasma cells or myeloma cells form tumors in the bones or soft tissues of the body.
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It is estimated that 12,830 deaths (7,190 men and 5,640 women) from this disease will occur this year. The 5-year survival rate tells you what percent of people live at least 5 years after the cancer is found. Percent means how many out of 100. The overall 5-year survival rate for people with multiple myeloma is 54%.
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SMM is traditionally defined as an asymptomatic disease with an increased clonal burden, the presence of: Serum monoclonal protein IgG or IgA ≥3 g/dL or. Urinary monoclonal (M) protein ≥500mg per 24 hours or. Clonal BPMC of 10–60%