do nsaids cause kidney damage?
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NSAIDs may cause an increased risk of sudden kidney failure and even progressive kidney damage.
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Valtrex Interactions Drugs that cause kidney problems, like a non-steroidal anti-inflammatory drug (NSAID) like ibuprofen or naproxen, can interact with Valtrex. Since Valtrex is very similar to acyclovir (Zovirax), you should not take the two medications at the same time.
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When unopposed, this may lead to acute tubular necrosis and acute renal failure. NSAIDs also produce interstitial nephritis with or without nephrotic syndrome secondary to minimal change disease. Although this presents as acute renal failure, it can progress in some cases to chronic renal failure.
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Examples of common human NSAIDs include ibuprofen, naproxen sodium, diclofenac, etc. Any type of NSAID should never be given to your dog or cat without consultation with your veterinarian. When NSAIDs are ingested in toxic amounts, it can result in severe gastric ulceration and acute kidney failure in dogs and cats.
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Growing evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs), while able to alleviate inflammation, may damage articular cartilage, though both chondrodestructive and chondroprotective activities have been observed with different NSAIDs.
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NSAIDs such as ibuprofen may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death.
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Yes, ibuprofen can cause hematuria (blood in the urine). Due to you having blood in your urine it would most likely be recommended that you do not take ibuprofen or other NSAID in the future, unless you have been prescribed them. Other non-steroidal anti-inflammatory (NSAID) drugs may cause the same side effect.
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NSAIDs are usually safe for dogs and have few side effects. But in some cases, they can cause kidney, liver, or digestive problems. You may be able to tell if your dog is having a bad reaction to an NSAID.
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Ibuprofen and other NSAIDs rarely affect the liver. Unlike acetaminophen (Tylenol), most NSAIDs are absorbed completely and undergo negligible liver metabolism. In other words, the way NSAIDs are metabolized makes liver injury ( hepatotoxicity) very rare.
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When taken as directed, regular use of aspirin does not seem to increase the risk of kidney disease in people who have normal kidney function. However, taking doses that are too large (usually more than six or eight tablets a day) may temporarily- and possibly permanently- reduce kidney function.
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NSAIDs possibly damage the normal large intestine, which presents as ulceration, colitis and stricture. Even though several studies found that NSAIDs can cause diverticular bleeding and perforation, flare-up of inflammatory bowel disease ,and play a role as an etiologic factor in lymphocytic colitis.
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What to avoid. If your kidney function is less than 50%, avoid painkillers containing aspirin or ibuprofen (unless a doctor specifically prescribes them for you). They can worsen the function of damaged kidneys. Ibuprofen should also be avoided if you're taking anti-rejection medicines after a kidney transplant.
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An overdose of these medications may cause stomach upset, abdominal pain, and vomiting. Larger amounts of NSAIDs can injure the kidneys. Also, they may cause ulcers, bleeding, seizures, and coma.
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Ibuprofen (Advil, Motrin) The Bad: Can impair kidney function, more so if taken before or during a run. (NSAIDs inhibit blood-flow to the kidneys. Kidney circulation can also be suppressed by dehydration.
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Decreased sodium excretion can result in weight gain, peripheral edema, attenuation of the effects of antihypertensive agents, and rarely aggravation of congestive heart failure. Although rare, NSAIDs can cause hyponatremia by reducing renal free water clearance.
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Further, prescription NSAIDs have been associated with improvements in nocturia and other urinary symptoms in clinical investigations (9–13). In contrast, 2 large studies of men reported associations between NSAID use and increased risk of acute urinary retention (7), nocturia, and benign prostatic hyperplasia (14).