fgf21 is an exocrine pancreas secretagogue?
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Abstract. The metabolic stress hormone FGF21 is highly expressed in exocrine pancreas, where its levels are increased by refeeding and chemically induced pancreatitis. ... Thus, pancreatic FGF21 is a digestive enzyme secretagogue whose physiologic function is to maintain acinar cell proteostasis.
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Pancreatic Lymph Nodes Are Early Targets of T Cells During Adoptive Transfer of Diabetes in NOD Mice.
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A secretory protein is any protein, whether it be endocrine or exocrine, which is secreted by a cell. Secretory proteins include many hormones, enzymes, toxins, and antimicrobial peptides. Secretory proteins are synthesized in the endoplasmic reticulum.
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Method of secretion Exocrine glands are named apocrine glands, holocrine glands, or merocrine glands based on how their products are secreted. Merocrine secretion – cells excrete their substances by exocytosis; for example, pancreatic acinar cells.
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Secretion. Exocrine glands secrete enzymes, ions, water, mucins and other substances into the digestive tract. The glands are situated within the gastrointestinal tract, in the walls of the stomach and intestines, or outside it (salivary glands, pancreas, liver, see above).
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As a digestive organ, the pancreas secretes pancreatic juice that contains digestive enzymes that assist the absorption of nutrients and digestion in the small intestine. These enzymes help to further break down the carbohydrates, proteins, and lipids in the chyme.
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The pancreas is a tubuloalveolar gland and has exocrine and endocrine tissues. The exocrine is the larger of the two parts and secretes pancreatic juice; a solution containing enzymes for carbohydrate, protein and triacylglycerol digestion. Pancreatic juice drains into the small intestine where it is functional.
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The pancreas is an organ located in the abdomen. It plays an essential role in converting the food we eat into fuel for the body's cells. The pancreas has two main functions: an exocrine function that helps in digestion and an endocrine function that regulates blood sugar.
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Pancrelipase (marketed as Pancreaze, Creon and Zenpep) Information. FDA has approved pancrelipase for adult and pediatric patients with exocrine pancreatic insufficiency (EPI) due to cystic fibrosis (CF), chronic pancreatitis, and other conditions.
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The pancreas is both an exocrine organ and an endocrine organ. This chapter is devoted to the exocrine pancreas. The exocrine pancreas is responsible for secretion of digestive enzymes, ions and water into the duodenum of the gastrointestinal tract.
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The pancreas is one of the most important endocrine glands. It is responsible for the secretion of insulin, a hormone that regulates the amount of sugar in the blood.
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Introduction. Pancreatic acinar cells synthesize and secrete almost all the digestive enzymes active in the lumen of the small intestine which are necessary for nutrient digestion. Both synthesis and secretion are highly regulated over both short and long time frames to insure an appropriate supply of digestive enzymes ...
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In digestion in people with CF, the small tubes that transport these enzymes out of the pancreas become blocked with mucus. The enzymes build up in the pancreas instead of reaching the digestive system (specifically, the lumen of the gut), causing the pancreas to become inflamed.
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function in digestive systems of animals other mammals, an alpha-amylase called ptyalin is produced by the salivary glands, whereas pancreatic amylase is secreted by the pancreas into the small intestine.
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Phosphofructokinase (PFK) is an enzyme that functions in the cytoplasm during glycolysis. Insulin, a protein that regulates blood sugar levels, is secreted from specialized pancreatic cells. ... There are two general targeting pathways for nuclear-encoded proteins in eukaryotic cells.
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Zymogen granules can be found in the acinar cells of the pancreas and salivary glands. They release zymogens outside the cell and into the body by a process called exocytosis.
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Endocrine Function: The endocrine component of the pancreas consists of islet cells (islets of Langerhans) that create and release important hormones directly into the bloodstream. Two of the main pancreatic hormones are insulin, which acts to lower blood sugar, and glucagon, which acts to raise blood sugar.