what is the difference between an anticoagulant and a thrombolytic agent?
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Antiplatelets, as the name implies, work by preventing platelets from clumping and forming a clot. Anticoagulants don't work on platelets. They do their work by inhibiting clotting factors which are part of the coagulation cascade.
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Anticoagulants such as heparin or warfarin (also called Coumadin) slow down your body's process of making clots. Antiplatelet drugs, such as aspirin, prevent blood cells called platelets from clumping together to form a clot. When you take a blood thinner, follow directions carefully.
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There are two main types of blood thinners. Anticoagulants such as heparin or warfarin (also called Coumadin) slow down your body's process of making clots. Antiplatelet drugs, such as aspirin, prevent blood cells called platelets from clumping together to form a clot.
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Fondaparinux (Arixtra) is an anticoagulant that shares the same pentasaccharide sequence as UFH and LMWH for the binding to antithrombin, however it has no extra chain and thus, is not considered a heparin product. It is also known to not cause HIT, as seen with UFH and LMWH.
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The anticoagulant effects of heparin are typically reversible with protamine sulfate, while protamine's effect on LMWH is limited. LMWH has less of an effect on thrombin compared to heparin, but about the same effect on Factor Xa.
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Aspirin and warfarin (Coumadin, Jantoven) are used to prevent blood clots. Aspirin is also used to treat fever, pain, and inflammation in the body. Aspirin and warfarin belong to different drug classes. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) and warfarin is an anticoagulant.
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Medical uses Because LMWH has more predictable pharmacokinetics and anticoagulant effect, LMWH is recommended over unfractionated heparin for patients with massive pulmonary embolism, and for initial treatment of deep vein thrombosis. ... An anti-factor Xa activity may be useful for monitoring anticoagulation.
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In the western world, warfarin is given as oral anticoagulant. Both acitrom and warfarin belong to the same class of acenocoumarol drugs and exist in R- and S- enantiomeric forms.
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Hemostasis involves three basic steps: vascular spasm, the formation of a platelet plug, and coagulation, in which clotting factors promote the formation of a fibrin clot. Fibrinolysis is the process in which a clot is degraded in a healing vessel. Anticoagulants are substances that oppose coagulation.
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How do they work? NOACs interrupt part of the complex system involved in the formation of blood clots. This causes the blood to take longer to clot and reduces the risk of AF-related stroke. All of the NOACs have been shown to be as effective at preventing strokes as warfarin.
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Heparin thins the blood, but newer drugs that actively break up the clots (thrombolytics) may act more quickly and may be more effective. These newer drugs include streptokinase, urokinase, and recombinant tissue -type plasminogen activator.
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Apart from streptokinase, all thrombolytic drugs are administered together with heparin (unfractionated or low molecular weight heparin), usually for 24 to 48 hours. Thrombolysis is usually intravenous.
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TXA is an antifibrinolytic agent that decreases clot breakdown and has anti-inflammatory effects in trauma patients. In the CRASH-2 and MATTERs trials, TXA was shown to safely decrease mortality without increasing the rates of vascular occlusive events.
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What is the difference between haemophilia A and B in terms of treatments? The main difference is that they need injections to replace different clotting factors. In haemophilia A, factor VIII (8) is missing. In haemophilia B, it is factor IX (9) that is missing.
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Thrombolytics can stop a heart attack that would otherwise be larger or potentially deadly. Outcomes are better if you receive a thrombolytic drug within 12 hours after the heart attack starts. But the sooner treatment begins, the better the results. The drug restores some blood flow to the heart in most people.
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Anticoagulants are the mainstay of prevention and treatment of venous thromboembolism because fibrin is the predominant component of venous thrombi. Antiplatelet drugs are less effective than anticoagulants in this setting because of the limited platelet content of venous thrombi.
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Warfarin sodium (Coumadin®, Jantoven®) is a medicine that is also known as a “blood thinner.” It helps to stop blood clots from forming and can also stop an active clot from getting bigger.