how common is it to get sickle cell disease?
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Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans. The disease is estimated to occur in 1 in 500 African Americans and 1 in 1,000 to 1,400 Hispanic Americans.
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Sickle cell anemia is a common and disabling disorder profoundly affecting mortality as well as quality of life. Up to 35% of men with sickle cell disease are affected by painful, prolonged erections termed ischemic priapism. A priapic episode may result in fibrosis and permanent erectile dysfunction.
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Pain is a common problem for people with sickle cell disease. It happens when the sickle-shaped red blood cells that cause the condition get stuck in small blood vessels and block blood flow. That can cause a pain episode or crisis to start suddenly, usually in the lower back, arms, legs, chest, and belly.
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Episodes of pain known as sickle cell crises are one of the most common and distressing symptoms of sickle cell disease. They happen when blood vessels to part of the body become blocked. The pain can be severe and lasts for up to 7 days on average.
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Complications of sickle cell disease occur because the sickled cells block blood flow to specific organs. The worst complications include stroke, acute chest syndrome (a condition that lowers the level of oxygen in the blood), organ damage, other disabilities, and in some cases premature death.
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What is the difference between sickle cell trait and sickle cell disease? People with sickle cell trait carry only one copy of the altered hemoglobin gene and rarely have any clinical symptoms related to the disease. In contrast, people with sickle cell disease carry two copies of the altered hemoglobin gene.
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Sickle cell disease is an inherited disease caused by defects, called mutations, in the beta globin gene that helps make hemoglobin. Normally, hemoglobin in red blood cells takes up oxygen in the lungs and carries it through the arteries to all the cells in the tissues of the body.
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When a person has two hemoglobin S genes (hemoglobin SS), the disease is called sickle cell anemia. This is the most common and often most severe type of sickle cell disease. Hemoglobin SC disease and hemoglobin Sβ thalassemia are two other common types of sickle cell disease.
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How sickle cell disease is inherited. Genes come in pairs. You inherit 1 set from your mother and 1 set from your father. To be born with sickle cell disease, a child has to inherit a copy of the sickle cell gene from both their parents.
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In the United States SCD affects approximately 100,000 Americans. SCD occurs among about 1 out of every 365 Black or African-American births. SCD occurs among about 1 out of every 16,300 Hispanic-American births. About 1 in 13 Black or African-American babies is born with sickle cell trait (SCT).
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To be born with sickle cell disease, a child has to inherit a copy of the sickle cell gene from both their parents. This usually happens when both parents are "carriers" of the sickle cell gene, also known as having the sickle cell trait.
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Sickle cell anaemia is an inherited autosomal recessive disorder. The leading causes of death in sickle cell diseases (SCD) are infection, pain episodes, acute chest syndrome and stroke [1, 2]. Death can be sudden and unexpected in sickle cell anaemia [1].
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Background Sickle cell disease is associated with multiple neurological complications including stroke, seizures, headaches. 10-14% of patients experience seizures but the incidence of status epilepticus is unknown.
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Approximately 5,000 Canadians, including children, have sickle cell disease. Sickle cell disease is an inherited blood disorder that can shorten the life of affected individuals by more than 30 years.
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Sickle cell disease is a very rare condition in Australia. It's most common among people of African, Caribbean, eastern Mediterranean, Indian or Middle Eastern descent (CGE 2015, NHS 2016a, Tidy 2015b). Sickle cell disease causes the body to sometimes make abnormal haemoglobin.
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Fever is a common presenting symptom for many manifestations of sickle cell disease (SCD). In particular, fever is frequently the first indication of serious and life-threatening bacterial infections.
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How Is Sickle Cell Disease Diagnosed? Sickle cell disease usually is found at birth with a blood test during routine newborn screening tests. A second blood test (called a hemoglobin electrophoresis) will confirm the diagnosis.