is meoh a strong nucleophile?
441066
Water and methanol are bad nucleophiles, but if you deprotonate them, they become good nucleophiles. 2. Nucleophilicity decreases to the right in the periodic table. So nitrogen is more nucleophilic than oxygen which is more nucleophilic than fluorine.
480520
Or how are you suppsed to know that NaSH is a stong nucleophile but a weak base? ... The base strength is related to the thermodynamic stability of the conjugate base.
842500
1 Answer. Truong-Son N. Pretty much never. A nucleophile MUST be a Lewis base, and there is a very poor chance that HBr will donate electrons BEFORE it donates its proton; its pKa is about −9 , i.e. it's a pretty strong acid.
182320
If one of the ions is OH-, the solution is basic. An example of a strong base is sodium hydroxide (NaOH). There are other ions that make acidic and basic solutions, but we won't be talking about them here.
938560
Why is NaOCH3 a strong nuc and strong base? These are strong nucleophiles because it's attached to a metallic group Na+ so it's automatically a negative anion.
373446
With a pKa of around 16–19, they are, in general, slightly weaker acids than water. With strong bases such as sodium hydride or sodium they form salts called alkoxides, with the general formula RO− M+. The acidity of alcohols is strongly affected by solvation. In the gas phase, alcohols are more acidic than in water.
372337
SCH3- Since NaSCH3 is a weak base but a very strong nucleophile this means that alkyl halides undergoes an SN2 substitution rather and elimination is that right or not??
1264685
Yes indeed, epoxides have both nucleophilic and electrophilic properties. They are very reactive due to the ring strain imposed by the sharp C-O-C bond angles. This is relieved when the ring opens upon nucleophilic attack, and the resulting molecule is at a lower energy state.
1334439
What it's used for: NaNH2 is a strong base and excellent nucleophile. It's used for deprotonation of weak acids and also for elimination reactions. Similar to: LDA (lithium diisopropylamide). The NH2- anion is the conjugate base of ammonia (NH3).
978194
SH- is less basic than OH-, but is a FAR GREATER nucleophile. Sulfur is large, and the electronegativity is less than Oxygen, hence the electrons are more loosely held. This renders it a greater nucleophile.
1188103
With the full negative charge localized on the single oxygen atom, it is a strong base, but the steric bulk from the methyl groups makes t-butoxide a rather poor nucleophile. Other non-nucleophilic bases include NaH, LDA, and DBU. The conjugate bases of the mineral acids make good nucleophiles, but terrible bases.
206321
Take a species like NaOH. It's both a strong base and a good nucleophile. When it's forming a bond to hydrogen (in an elimination reaction, for instance), we say it's acting as a base. Similarly, when it's forming a bond to carbon (as in a substitution reaction) we say it's acting as a nucleophile.
1360378
Either of these two compounds are not acids in water and mostly not even in most non-aqueous solvents. ... So the statement that ammonia is a stronger acid than CH4 is correct. Inliquid ammoniathere is some ionization just as in water:NH3(l) + NH3(l) NH4+ + NH2-, but no ionization of CH4 in liquid CH4.
1166768
A polar aprotic solvent like acetone does not hydrogen bond to ethoxide ion to a significant extent. So the ethoxide ion is almost a "bare" nucleophile. It is better able to attack the substrate and is therefore a stronger nucleophile.
25816
2-‐bromopentane is secondary: a) NaOEt is a strong nucleophile and strong base. The substrate in this case is secondary. Therefore, we expect SN2 with a possible minor E2 b) NaI is a strong nucleophile and weak base. DMSO is a polar aprotic solvent.
418604
No, it can't be generalised. Amongst the haloacids, only HF is weak. Acid strength can be determined by the stability of the conjugate base (for most acids, the conjugate base is what you get when you remove H+ from the acid). ... HCl,HBr,HI are all strong acids.
107207
Yes, that's right. Tertiary alcohols readily undergo elimination to yield alkenes, then the KMNO4 reacts with the alkene to give syn dihydroxylation.