what sickle cell anemia affects?
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Any and all major organs are affected by sickle cell disease. The liver, heart, kidneys, gallbladder, eyes, bones, and joints can suffer damage from the abnormal function of the sickle cells and their inability to flow through the small blood vessels correctly. Problems may include the following: Increased infections.
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In sickle cell anemia, the red blood are shaped like sickles or crescent moons. These rigid, sticky cells can get stuck in small blood vessels, which can slow or block blood flow and oxygen to parts of the body.
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Signs and symptoms of sickle cell disease usually begin in early childhood. Characteristic features of this disorder include a low number of red blood cells (anemia), repeated infections, and periodic episodes of pain. The severity of symptoms varies from person to person.
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In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. Both mother and father must pass the defective form of the gene for a child to be affected.
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When red blood cells sickle, they break down prematurely, which can lead to anemia. Anemia can cause shortness of breath, fatigue, and delayed growth and development in children. The rapid breakdown of red blood cells may also cause yellowing of the eyes and skin, which are signs of jaundice.
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Sickle cell anemia can lead to a host of complications, including: Stroke. Sickle cells can block blood flow to an area of your brain. Signs of stroke include seizures, weakness or numbness of your arms and legs, sudden speech difficulties, and loss of consciousness.
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Sickle cell anemia can lead to a wide range of complications that may require treatment. Some examples include: hearing loss, vision problems, acute chest syndrome, jaundice, priapism (persistent and painful erections), leg ulcers, gallstones, and stroke.
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Dehydration and reduced oxygen levels in a person's blood resulting from strenuous exercise may cause red blood cells to sickle. Children with sickle cell disease can usually exercise and play normally if they: Drink plenty of fluids before, during, and after exercise. Dehydration can cause cells to sickle.
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People with sickle cell disease have red blood cells that contain mostly hemoglobin S, an abnormal hemoglobin type. These red blood cells are stiff, distorted in shape (like a sickle) and sometimes block small blood vessels.
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- Sickle Cell Disease. Sickle cell disease is an inherited disease caused by defects, called mutations, in the beta globin gene that helps make hemoglobin. Normally, hemoglobin in red blood cells takes up oxygen in the lungs and carries it through the arteries to all the cells in the tissues of the body.
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Yes, they can. Sickle cell disease can affect people of ANY race or ethnicity. Sickle cell disease, an inherited disorder of the red blood cells, is more common in African Americans in the U.S. compared to other ethnicities—occurring in approximately 1 in 365 African Americans.
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Some examples include: hearing loss, vision problems, acute chest syndrome, jaundice, priapism (persistent and painful erections), leg ulcers, gallstones, and stroke. Sickle cell anemia also can have a negative impact on the mental health of patients and may lead to depression and anxiety.
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Symptoms. Signs and symptoms of sickle cell anemia usually appear around 5 months of age. They vary from person to person and change over time.
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Having sickle cell disease alone does not affect learning ability, but the complications of the disease may cause learning problems. Students may require extra help and encouragement when illness interferes with school. Fatigue due to anemia and sleep disturbances may be present.
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Sickle cell anemia is one of a group of diseases termed hemoglobinopathies, in which hemoglobin A is partly or completely replaced by abnormal sickle hemoglobin S. It is caused by the inheritance of a gene for a structurally abnormal portion of the hemoglobin chain.
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With SCD, the hemoglobin in red blood cells is abnormal. This damages the red blood cells. SCD prevents the hemoglobin in red blood cells from carrying oxygen to all parts of the body. Sickle cells clump together, blocking small blood vessels and causing painful and damaging problems.
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Management of sickle cell anemia is usually aimed at avoiding pain episodes, relieving symptoms and preventing complications. Treatments might include medications and blood transfusions. For some children and teenagers, a stem cell transplant might cure the disease.