how does type 1 diabetes affect the skeletal system?
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How diabetes affects the bones. People with diabetes mellitus, types 1 and 2, have an increased risk of osteoporosis, a condition which causes bones to weaken. Risk factors for osteoporosis include the duration of diabetes and how well controlled blood glucose levels are.
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What causes type 1 diabetes? Type 1 diabetes occurs when your immune system, the body's system for fighting infection, attacks and destroys the insulin-producing beta cells of the pancreas. Scientists think type 1 diabetes is caused by genes and environmental factors, such as viruses, that might trigger the disease.
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People suffering from type 1 and type 2 diabetes are more likely to be at risk from heart attacks, strokes and high blood pressure. Vascular problems, such as poor circulation to the legs and feet, are also more likely to affect diabetes patients.
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Both type 1 and type 2 diabetes cause damage to blood vessels and peripheral nerves that can result in problems in the legs and feet. Two main conditions, 1) peripheral artery disease (PAD), and 2) peripheral neuropathy are responsible for the increased risk of foot problems in people with diabetes.
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Type 1 diabetes is an autoimmune disease. The pancreas can't make insulin because the immune system attacks it and destroys the cells that produce insulin. Kids and teens with type 1 diabetes are at risk for other autoimmune problems, but these aren't actually caused by the diabetes.
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Profound metabolic changes occur in people with type 1 diabetes mellitus during insulin deprivation. These include an increase in basal energy expenditure and reduced mitochondrial function. In addition, protein metabolism is significantly affected during insulin deprivation.
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Uncontrolled type 1 diabetes can lead to a life-threatening complication called diabetic ketoacidosis. Without insulin, cells cannot take in glucose. A lack of glucose in cells prompts the liver to try to compensate by releasing more glucose into the blood, and blood sugar can become extremely high.
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The pancreas and type 1 diabetes In type 1 diabetes, the beta cells that produce insulin are attacked by the body's immune system. As more beta cells get killed off, the pancreas struggles to produce enough insulin to keep blood sugar levels down and the symptoms of diabetes begin to appear.
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Type 1 diabetes occurs when your immune system, the body's system for fighting infection, attacks and destroys the insulin-producing beta cells of the pancreas. Scientists think type 1 diabetes is caused by genes and environmental factors, such as viruses, that might trigger the disease.
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Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of β cells of the endocrine pancreas. Pathogenesis of T1DM is different from that of type 2 diabetes mellitus, where both insulin resistance and reduced secretion of insulin by the β cells play a synergistic role.
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If you have Type 1 diabetes, research shows that you may be more predisposed to certain types of gum and teeth disease. Having diabetes itself isn't usually the cause of these problems, but diabetes makes it easier for you to get them and often makes them worse.
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Diabetes can cause joint pain in various ways, including by damaging the joints or nerves. It also has links with two types of arthritis. Over time, uncontrolled diabetes can affect the muscles and skeleton, leading to joint pain, nerve damage, and other symptoms.
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We found that, on average, type 1 diabetes confers an excess incidence of several cancers. In particular, persons with type 1 diabetes had a higher incidence of cancer of the liver, pancreas, kidney, endometrium and ovary and a lower incidence of prostate cancer than those in the general population.
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It has been suspected that childhood vaccinations may alter the immune system, thereby increasing the risk of autoimmune reactions. However, previous studies have not found any evidence to support the association between vaccination and an increased risk of type 1 diabetes.
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Diabetes and foot problems facts People with diabetes have an increased risk of ulcers and damage to the feet. Diabetic foot problems also include bunions, corns, calluses, hammertoes, fungal infections, dryness of the skin, and ingrown toenails.
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Regular doses of vitamin D early in life have been shown to reduce the risk of developing type 1 diabetes. Vitamin D treatment has also been shown to improve glycemic control and insulin sensitivity in people with type 1 and type 2 diabetes and in normal individuals.
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A series of studies have reported a constant global rise in the incidence of type 1 diabetes. Epidemiological and immunological studies have demonstrated that environmental factors may influence the pathogenesis, leading to a cell-mediated pancreatic β-cell destruction associated with humoral immunity.