is aricept a cholinesterase inhibitor?
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The U.S. Food and Drug Administration (FDA) has approved two types of medications — cholinesterase inhibitors (Aricept®, Exelon®, Razadyne®) and memantine (Namenda®) — to treat the cognitive symptoms (memory loss, confusion, and problems with thinking and reasoning) of Alzheimer's disease.
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Acetylcholinesterase is the hydrolase enzyme involved in the breakdown of acetylcholine. This enzyme is present in the synaptic cleft and breaks down acetylcholine into choline and acetate. These inactive metabolites can then re-cycle acetylcholine after diffusing back into the pre-synaptic membrane.
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Acetylcholine esterase (AChE) inhibitors are considered to be the basic treatment of myasthenia gravis (MG). Edrophonium is primarily used as a diagnostic tool owing to its short half-life. Pyridostigmine is used for long-term maintenance. High doses of corticosteroids commonly are used to suppress autoimmunity.
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Angiotensin-Converting Enzyme (ACE) Inhibitors Enalapril (Vasotec) Fosinopril (Monopril) Lisinopril (Prinivil, Zestril) Perindopril (Aceon)
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["Donepezil (marketed under the brand name Aricept), which is approved to. treat all stages of Alzheimer's disease.", 'Galantamine (Razadyne), approved for mild-to-moderate stages.', "Rivastigmine (Exelon), approved for mild-to-moderate Alzheimer's as well."]
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Donepezil, rivastigmine and galantamine all prevent an enzyme called acetylcholinesterase from breaking down acetylcholine. This means there is a higher concentration of acetylcholine in the brain, which leads to better communication between nerve cells. This may ease some symptoms of Alzheimer's disease for a while.
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Practice Essentials. Pseudocholinesterase deficiency is an inherited enzyme abnormality that results in abnormally slow metabolic degradation of exogenous choline ester drugs such as succinylcholine and mivacurium.
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Medications. The following are used to temporarily improve dementia symptoms. Cholinesterase inhibitors. These medications — including donepezil (Aricept), rivastigmine (Exelon) and galantamine (Razadyne) — work by boosting levels of a chemical messenger involved in memory and judgment.
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ACE inhibitors and angiotensin receptor blockers (ARBS) are used to treat high blood pressure and heart failure, and all have diarrhea as a reported side effect. The ARB olmesartan (Benicar, Azor) is the biggest offender in this class of drugs and diarrhea can be severe and long lasting while you're taking it.
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Medications called cholinesterase inhibitors are prescribed for mild to moderate Alzheimer's disease. These drugs may help reduce some symptoms and help control some behavioral symptoms. The medications are Razadyne® (galantamine), Exelon® (rivastigmine), and Aricept® (donepezil).
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ARICEPT 10 (Aricept 10 mg) Aricept is used in the treatment of alzheimer's disease and belongs to the drug class cholinesterase inhibitors. Risk cannot be ruled out during pregnancy. Aricept 10 mg is not a controlled substance under the Controlled Substances Act (CSA).
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Namzaric (memantine hydrochloride extended-release and donepezil hydrochloride) is a combination of an orally active NMDA receptor antagonist, and a reversible inhibitor of the enzyme acetylcholinesterase, used to treat moderate to severe dementia of the Alzheimer's type in patients stabilized on memantine ...
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Huperzine A acts as a cholinesterase inhibitor — a type of medication that works by improving the levels of neurotransmitters in the brain. Small early studies suggest that huperzine A might improve memory and protect nerve cells, which could slow the cognitive decline associated with Alzheimer's.
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Three studies have found a positive association between dementia and omeprazole, esomeprazole, lansoprazole, and pantropazole, with an approximately 1.4-fold increased risk of any dementia in cohorts using PPIs (95% CI, 1.36–1.52; P < 0.001) [76].
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Anticholinergics for depression, such as amitriptyline, dosulepin, and paroxetine, have previously been linked to higher risk of dementia, even when they were used up to 20 years beforehand. Some studies have also suggested that use of any anticholinergic is linked to raised risk of dementia.
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Deficiencies in acetylcholine can lead to myasthenia gravis, which is characterized by muscle weakness. Too little acetylcholine may also lead to Alzheimer's disease; symptoms include a decline in cognitive abilities and memory loss.
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The cholinergic system has been considered to play a relevant role in asthma, according to the well-known increased bronchial responsiveness to cholinergic stimuli; however, the different attempts to prevent or attenuate the allergen-induced airway inflammation by atropine were ineffective.