what are the long term effects of taking methotrexate?
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If you are using methotrexate long term, a liver biopsy is usually recommended. Methotrexate use has rarely caused serious (sometimes fatal) side effects, such as lung problems, lung infections (Pneumocystis jiroveci pneumonia), skin reactions, diarrhea, and mouth sores (ulcerative stomatitis).
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What is the difference between taking methotrexate tablets versus the injection? There is good evidence that injectable methotrexate is more reliably effective than tablets, particularly as the dose increases. The risk of some side effects may also be less compared to the tablet form.
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Taking folic acid Folic acid helps protect the healthy cells in your body and reduces some of the side effects of methotrexate. It can make you less likely to be sick (vomit) or get diarrhoea. Your doctor will usually start you on one 5mg folic acid tablet, taken once a week. Take it the day after your methotrexate.
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The more serious side effects of isotretinoin can have long-term or permanent effects. However, apart from increased cholesterol and joint and muscle problems, these side effects are all quite rare.
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Taking omeprazole for more than a year may increase your chances of certain side effects, including: bone fractures. gut infections. vitamin B12 deficiency – symptoms include feeling very tired, a sore and red tongue, mouth ulcers and pins and needles.
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['Crusting of the skin.', 'difficulty in wearing contact lenses (may continue after medicine is stopped)', 'dryness of the eyes (may continue after treatment is stopped)', 'dryness of the mouth or nose.', 'dryness or itching of the skin.', 'headache (mild)', 'increased sensitivity of the skin to sunlight.']
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You must not get pregnant for at least 3 months after having a methotrexate injection. If you're sexually active, you need to use a reliable method of birth control. Talk to your doctor or healthcare provider if you have questions about birth control.
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['Fatigue. Tiredness (fatigue) is the most common side effect of both chemotherapy and radiation. ... ', 'Flu-like Symptoms. ... ', 'Pain. ... ', 'Mouth, Gum, and Throat Sores. ... ', 'Gastrointestinal Problems. ... ', 'Skin Changes. ... ', 'Weight Changes. ... ', 'Hair Loss.']
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['Risk of infection. This treatment can reduce the number of white blood cells in your blood. ... ', 'Anaemia (low number of red blood cells) ... ', 'Bruising and bleeding. ... ', 'Diarrhoea. ... ', 'Constipation. ... ', 'Feeling sick. ... ', 'Sore mouth. ... ', 'Muscle or joint pain.']
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Taking methotrexate in pregnancy may lead to birth abnormalities that affect a child's physical and mental development. In some cases, methotrexate can result in fetal death. Examples of birth abnormalities that methotrexate may cause include: Neural tube defects that affect the brain, spine, or spinal cord.
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These drugs can slow the progression of rheumatoid arthritis and save the joints and other tissues from permanent damage. Common DMARDs include methotrexate (Trexall, Otrexup, others), leflunomide (Arava), hydroxychloroquine (Plaquenil) and sulfasalazine (Azulfidine).
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['headache.', 'dizziness.', 'loss of appetite.', 'nausea.', 'diarrhea.', 'stomach pain.', 'vomiting.', 'rash.']
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The methotrexate will stop the pregnancy and the level of pregnancy hormone in your blood should decrease over 2 to 4 days.
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Your doctor may give you medicines to help prevent certain side effects before they happen. Some chemo drugs cause long-term side effects, like heart or nerve damage or fertility problems. Still, many people have no long-term problems from chemo. Ask your doctor if the chemo drugs you're getting have long-term effects.
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How long does it take to feel the effects of methotrexate on rheumatoid arthritis? It can take three to six weeks to start to feel your methotrexate work. It takes even longer -- 12 weeks -- to get the full effects.
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Side effects associated with the treatment in the first 18 months included cutaneous reactions in 14 patients and increased liver enzymes in two patients; however, no further side effects were reported in the long-term group for up to 120 months of therapy.
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Sometimes the side effects can last a lifetime, such as when chemo causes long-term damage to the heart, lungs, kidneys, or reproductive organs. Certain types of chemo sometimes cause delayed effects, such as a second cancer that may show up many years later.