Problem statement: Answer the multiple-choice question.
Query: Which drug exhibits a 15.154\% hERG inhibition at a concentration of 1uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any additional words.
Options:
[a] COc1ccc2[nH]c3c(=O)n(CCCN4CCOCC4)cnc3c2c1
[b] O=C(Cn1nnc2ccccc21)NNC(=O)c1ccccc1
[c] CC(C)COP(=O)(c1ccc(N(C)C)cc1)C(O)c1ccccc1
[d] CCCCCCN(C(=O)CCCCCN1C(=O)NC(c2ccc(-c3ccccc3)cc2)C(C(=O)OCc2ccccc2)=C1C)C(C(=O)NCCCC)c1ccc(OCC(=O)OC)c(C(=O)OC)c1
[e] CC[C@@]12C(=O)N(c3cccc(Br)c3)C(=O)N1[C@H](c1cccc(C)c1)[C@@H]1C(=O)N(Cc3ccccc3)C(=O)[C@@H]12
Answer: e. CC[C@@]12C(=O)N(c3cccc(Br)c3)C(=O)N1[C@H](c1cccc(C)c1)[C@@H]1C(=O)N(Cc3ccccc3)C(=O)[C@@H]12
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
CC[C@@]12C(=O)N(c3cccc(Br)c3)C(=O)N1[C@H](c1cccc(C)c1)[C@@H]1C(=O)N(Cc3ccccc3)C(=O)[C@@H]12
CC[C@@]12C(=O)N(c3cccc(Br)c3)C(=O)N1[C@H](c1cccc(C)c1)[C@@H]1C(=O)N(Cc3ccccc3)C(=O)[C@@H]12
(1S,2R,7S,8R)-10-benzyl-4-(3-bromophenyl)-2-ethyl-7-(3-methylphenyl)-4,6,10-triazatricyclo[6.3.0.02,6]undecane-3,5,9,11-tetrone