Problem statement: Answer the multiple-choice question.
Question: Which drug exhibits a -3.608\% human ether-à-go-go related gene (hERG) inhibition at a concentration of 1uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
a) COc1cccc(NC(=O)CN(C)C(=O)c2ccc3c(c2)CC(c2ccccc2)OC3=O)c1
b) Cc1ccccc1CN1CCN(CC2CC3C=CC2C3)CC1
c) Cc1nonc1CN(C)C(=O)c1ccc(OC2CCN(Cc3ccccn3)CC2)cc1
d) CC1CCCCC1NC(=O)CNC(=O)c1cccs1
e) Cc1ccc(-n2c(O)c(/C=C/C=Nc3ccccc3)c(=O)[nH]c2=O)cc1
Answer: c. Cc1nonc1CN(C)C(=O)c1ccc(OC2CCN(Cc3ccccn3)CC2)cc1
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
Cc1nonc1CN(C)C(=O)c1ccc(OC2CCN(Cc3ccccn3)CC2)cc1
Cc1nonc1CN(C)C(=O)c1ccc(OC2CCN(Cc3ccccn3)CC2)cc1
N-methyl-N-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]oxybenzamide