Problem statement: Answer the multiple choice question.
Question: Which compound exhibits a -9.548% human ether-à-go-go related gene (hERG) inhibition at 10uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
[a] CS(=O)(=O)N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1
[b] O=C(Nc1cccc(-c2nn[nH]n2)c1)c1cccs1
[c] O=C(OC1CCOC1=O)c1cc(-c2cccs2)nc2ccccc12
[d] CCN(CC)c1ccc(NC(=O)c2ccccc2OCC(=O)OC)cc1
[e] COc1ccc(C(CCN2CCN(c3ccccc3)CC2)c2c(OC)cc(OC)c3c(-c4ccccc4)cc(=O)oc23)cc1
Answer: e. COc1ccc(C(CCN2CCN(c3ccccc3)CC2)c2c(OC)cc(OC)c3c(-c4ccccc4)cc(=O)oc23)cc1
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_10uM#}{herg_central_at_10uM__units} {herg_central_at_10uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_10uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COc1ccc(C(CCN2CCN(c3ccccc3)CC2)c2c(OC)cc(OC)c3c(-c4ccccc4)cc(=O)oc23)cc1
COc1ccc(C(CCN2CCN(c3ccccc3)CC2)c2c(OC)cc(OC)c3c(-c4ccccc4)cc(=O)oc23)cc1
5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-(4-phenylpiperazin-1-yl)propyl]-4-phenylchromen-2-one