Task: Answer the multiple-choice question.
Question: Which compound exhibits a -19.882% human ether-à-go-go related gene (hERG) inhibition at 10uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
(a) c1cncc(-c2nc(-c3ccc4c(c3)OCO4)cs2)c1
(b) CC(C)(C)c1cc(S(=O)(=O)CCc2ccccn2)cc(C(C)(C)C)c1F
(c) Cc1cc(C)cc(OCC(=O)Nc2ccccc2N2CCCCC2)c1
(d) O=C(CSCc1ccc(Cl)cc1)Nc1ccc(-c2nnc(-c3ccccc3)o2)cc1
(e) COC(=O)[C@@]12CCCN1[C@H](c1ccc(-c3ccc(C(C)=O)cc3)c(OC)c1)[C@H]1C(=O)N(C)C(=O)[C@H]12.O=C(O)C(F)(F)F
Answer: e. COC(=O)[C@@]12CCCN1[C@H](c1ccc(-c3ccc(C(C)=O)cc3)c(OC)c1)[C@H]1C(=O)N(C)C(=O)[C@H]12.O=C(O)C(F)(F)F
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_10uM#}{herg_central_at_10uM__units} {herg_central_at_10uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_10uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COC(=O)[C@@]12CCCN1[C@H](c1ccc(-c3ccc(C(C)=O)cc3)c(OC)c1)[C@H]1C(=O)N(C)C(=O)[C@H]12.O=C(O)C(F)(F)F
COC(=O)[C@@]12CCCN1[C@H](c1ccc(-c3ccc(C(C)=O)cc3)c(OC)c1)[C@H]1C(=O)N(C)C(=O)[C@H]12.O=C(O)C(F)(F)F
methyl (3aS,4S,8aS,8bR)-4-[4-(4-acetylphenyl)-3-methoxyphenyl]-2-methyl-1,3-dioxo-3a,4,6,7,8,8b-hexahydropyrrolo[3,4-a]pyrrolizine-8a-carboxylate;2,2,2-trifluoroacetic acid