Problem statement: Answer the multiple-choice question.
Question: Which compound exhibits a -2.182% human ether-à-go-go related gene (hERG) inhibition at 10uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any additional words.
Options:
[a] COc1ccc(-c2nc(SC(C)C(=O)c3c(N)n(C)c(=O)n(C)c3=O)n[nH]2)cc1
[b] COc1ccc(CNC(=O)CCCNC(=O)c2cn(C)nc2C(F)(F)F)cc1
[c] Cc1ccc(NC(=O)C2CCCN2S(=O)(=O)c2ccc3c(c2)n(C)c(=O)c(=O)n3C)c(C)c1
[d] OCC[C@@H]1C[C@H](O)[C@@H](O)[C@@]2(OCCCc3ccccc32)O1
[e] O=C1CCCCCCCCCC/C(=N\O)CCCO1
Answer: b. COc1ccc(CNC(=O)CCCNC(=O)c2cn(C)nc2C(F)(F)F)cc1
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_10uM#}{herg_central_at_10uM__units} {herg_central_at_10uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_10uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COc1ccc(CNC(=O)CCCNC(=O)c2cn(C)nc2C(F)(F)F)cc1
COc1ccc(CNC(=O)CCCNC(=O)c2cn(C)nc2C(F)(F)F)cc1
N-[4-[(4-methoxyphenyl)methylamino]-4-oxobutyl]-1-methyl-3-(trifluoromethyl)pyrazole-4-carboxamide